Centre for Disease Modelling, York University, Toronto, ON, Canada.
Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Neuroinflammation. 2021 Nov 11;18(1):264. doi: 10.1186/s12974-021-02319-4.
This article presents the first detailed analysis of the prevalence and disability burden of Guillain-Barré syndrome (GBS) from 1990 to 2019 by cause, age, sex, and Socio-demographic Index (SDI) in 204 countries and territories.
Data from the Global Burden of Diseases Study (GBD) 2019 were used. GBD 2019 modelled the prevalence of GBS using hospital and claims data. Years lived with disability (YLDs) were estimated as the product of the GBS prevalence and the disability weight. This article also reported proportions in the age-standardised prevalence rate that were due to six underlying causes of GBS.
In 2019, there were 150,095 [95% uncertainty intervals (UI) 119,924 to 188,309] total cases of GBS worldwide, which resulted in 44,407 (95% UI 28,016 to 64,777) YLDs. Globally, there was a 6.4% (95% UI 3.6 to 9.5) increase in the age-standardised prevalence of GBS per 100,000 population between 1990 and 2019. High-income Asia Pacific [1.9 (95% UI: 1.5 to 2.4)] and East Asia [0.8 (95% UI: 0.6 to 1.0)] had the highest and lowest age-standardised prevalence rates (per 100,000), respectively, in 2019. Nationally, Japan [6.4 (95% UI: 5.3 to 7.7)] and China [0.8 (95% UI: 0.6 to 1.0)] had the highest and lowest age-standardised prevalence rates (per 100,000). The age-standardised burden of GBS increased with increasing age and was higher in males in all age groups. Furthermore, the age-standardised prevalence of GBS (per 100,000) had a positive association with the level of development, as measured by SDI, although this association was not strong. Upper respiratory infections and unknown causes accounted for the highest proportions of underlying causes.
Globally, the prevalence of GBS continues to increase. Geographical differences and strategies aimed at preventing infectious diseases should be considered in future health policy planning and decision-making processes. This study had several limitations, such as using the same disability weight for all causes and a reliance on hospital- and self-reported data, which should be addressed in future research.
本文首次详细分析了 1990 年至 2019 年期间 204 个国家和地区按病因、年龄、性别和社会人口指数（SDI）划分的 Guillain-Barré 综合征（GBS）的流行率和残疾负担。
使用全球疾病负担研究（GBD）2019 年的数据。GBD 2019 使用医院和索赔数据对 GBS 的流行率进行建模。残疾年数（YLDs）的估计值为 GBS 流行率与残疾权重的乘积。本文还报告了由于 GBS 的六个潜在病因而导致的年龄标准化患病率中所占的比例。
2019 年，全球有 150095 例（95%置信区间[95%UI]为 119924 至 188309 例）GBS 总病例，导致 44407 例（95%UI 为 28016 至 64777 例）YLDs。全球每 100000 人口的年龄标准化 GBS 患病率以每年 6.4%（95%UI 为 3.6%至 9.5%）的速度增长。2019 年，高收入亚太地区[1.9（95%UI：1.5 至 2.4）]和东亚[0.8（95%UI：0.6 至 1.0）]的年龄标准化患病率最高和最低，分别。在国家一级，日本[6.4（95%UI：5.3 至 7.7）]和中国[0.8（95%UI：0.6 至 1.0）]的年龄标准化患病率（每 100000 人）最高和最低。GBS 的年龄标准化负担随年龄的增长而增加，且在所有年龄组中男性的负担均较高。此外，GBS 的年龄标准化患病率（每 100000 人）与 SDI 所衡量的发展水平呈正相关，尽管这种相关性并不强。上呼吸道感染和未知原因占潜在病因的比例最高。
全球范围内，GBS 的流行率持续上升。在未来的卫生政策规划和决策过程中，应考虑地理差异和预防传染病的策略。本研究存在一些局限性，例如对所有病因使用相同的残疾权重以及依赖于医院和自我报告的数据，这些应在未来的研究中加以解决。
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