Sanchez-Landers Manuel, Rodriguez-Benites Arnold Frank
Facultad de Medicina, Universidad Nacional de Trujillo, Trujillo, Perú.
Departamento de Emergencia y Cuidados Críticos del Hospital Belén de Trujillo. Trujillo, Perú.
Rev Peru Med Exp Salud Publica. 2025 Jun 9;42(1):88-91. doi: 10.17843/rpmesp.2025.421.13893.
Guillain-Barré syndrome is a potentially severe autoimmune inflammatory polyneuropathy, which is usually associated with previous infections. Dengue is the most common arbovirus infection worldwide, being endemic in tropical and subtropical areas such as Peru. Scientific literature shows some reports of dengue with neurological complications, but its pathophysiology is not well understood. We present the case of a woman from an area endemic for dengue with Guillain-Barré syndrome with a disability scale of 4/6 on the Hughes scale, confirmed by albumin-cytological dissociation, and previous infection with dengue virus confirmed with a positive serum ELISA IgM test. The patient's progress was favorable after receiving intravenous immunoglobulin. It is important to consider this viral infection as a probable risk factor for developing Guillain-Barré syndrome.
吉兰-巴雷综合征是一种潜在的严重自身免疫性炎性多发性神经病，通常与既往感染有关。登革热是全球最常见的虫媒病毒感染，在秘鲁等热带和亚热带地区呈地方性流行。科学文献中有一些关于登革热伴发神经并发症的报道，但其病理生理学尚未完全明确。我们报告一例来自登革热地方性流行区的女性患者，患有吉兰-巴雷综合征，休斯量表残疾评分为4/6，经蛋白细胞分离确诊，血清ELISA IgM试验阳性证实既往感染登革热病毒。患者接受静脉注射免疫球蛋白后病情好转。将这种病毒感染视为吉兰-巴雷综合征发病的可能危险因素很重要。
