Sheffler Julia L, Meynadasy Melissa A, Taylor Diamond T, Kiosses Dimitris N, Hajcak Greg
Center for Translational Behavioral Science, Florida State University College of Medicine, Tallahassee, FL, USA.
Department of Psychology, Florida State University, Tallahassee, FL, USA.
Int Psychogeriatr. 2022 Dec;34(12):1035-1043. doi: 10.1017/S1041610221002623. Epub 2021 Nov 12.
To investigate the relationship between the P300 event-related potential, neuropsychological measures of memory, subjective memory complaints (SMCs), and indicators of psychosocial functioning.
DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study of 79 community-based older adults, aged 60-75 years, participants completed online surveys and in-person neuropsychological and electroencephalogram (EEG) assessments.
Measures included: the Change subscale of the , NIH Toolbox Emotions battery (Perceived Stress and Psychological Well-Being), , , electrocortical measures (EEG), , 3rd Edition, and diagnostic ratings for mild and major neurocognitive disorders based on full neuropsychological battery, clinical interview, and two-clinician consensus.
P300 amplitude was associated with long-delay verbal memory recall and diagnostic rating. SMCs were not associated with objective memory or diagnostic rating. SMCs were associated with higher perceived stress, anxiety, and depression symptoms and lower psychological well-being.
Neural indicators such as the P300 may be useful for early detection of cognitive impairment. SMCs were not a reliable indicator of early memory impairment in relation to neuropsychological or neural indicators, but may be a useful indicator of unreported stress and mood symptoms in clinical settings.
探讨P300事件相关电位、记忆的神经心理学测量、主观记忆抱怨（SMCs）与社会心理功能指标之间的关系。
设计、背景和参与者：在这项针对79名60 - 75岁社区老年人的横断面研究中，参与者完成了在线调查以及面对面的神经心理学和脑电图（EEG）评估。
测量内容包括：美国国立卫生研究院工具箱情绪量表（感知压力和心理健康）的变化子量表、……、脑电图测量（EEG）、……、第三版，以及基于完整神经心理学测试组、临床访谈和两位临床医生共识得出的轻度和重度神经认知障碍的诊断评级。
P300波幅与长时延迟言语记忆回忆及诊断评级相关。SMCs与客观记忆或诊断评级无关。SMCs与更高的感知压力、焦虑和抑郁症状以及更低的心理健康水平相关。
诸如P300之类的神经指标可能有助于早期发现认知障碍。就神经心理学或神经指标而言，SMCs并非早期记忆障碍的可靠指标，但在临床环境中可能是未报告的压力和情绪症状的有用指标。
