MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
School of Epidemiology and Public Health, University of Bristol, Bristol, UK.
Br J Ophthalmol. 2023 Apr;107(4):488-494. doi: 10.1136/bjophthalmol-2021-320231. Epub 2021 Nov 11.
To investigate effect of patient age, gender, comorbidities and surgeon on refractive outcomes following cataract surgery.
Study population: patients on UK national ophthalmic cataract database on cataract operations undertaken between 1 April 2010 and 31 August 2018. Variables examined included gender, age, diabetic retinopathy, glaucoma, high myopia, inherited retinal disease, optic nerve disease, uveitis, pseudoexfoliation, vitreous opacities, retinal pathology, cataract type, previous surgery and posterior capsular rupture. A multivariate normal cross-classified model was fitted to the refractive outcome using Markov Chain Monte Carlo (MCMC) methods with diffuse priors to approximate maximum likelihood estimation. A MCMC chain was generated with a burn-in of 5000 iterations and a monitoring chain of 50 000 iterations.
490 987 cataract operations were performed on 351 864 patients by 2567 surgeons. Myopic and astigmatic errors were associated with posterior capsule rupture (-0.38/+0.04×72), glaucoma (-0.10/+0.05×95), previous vitrectomy (-0.049/+0.03×66) and high myopia (-0.07/+0.03×57). Hyperopic and astigmatic errors were associated with diabetic retinopathy (+0.08/+0.03×104), pseudoexfoliation (+0.07/+0.01×158), male gender (+0.12/+0.05×91) and age (-0.01/+0.06×97 per increasing decade). Inherited retinal disease, optic nerve disease, previous trabeculectomy, uveitis, brunescent/white cataract had no significant impact on the error of the refractive outcome. The effect of patient gender and comorbidity was additive. Surgeons only accounted for 4% of the unexplained variance in refractive outcome.
Patient comorbidities and gender account for small but statistically significant differences in refractive outcome, which are additive. Surgeon effects are very small.
研究患者年龄、性别、合并症和外科医生对白内障手术后屈光结果的影响。
研究人群:英国国家眼科白内障数据库中 2010 年 4 月 1 日至 2018 年 8 月 31 日期间接受白内障手术的患者。检查的变量包括性别、年龄、糖尿病视网膜病变、青光眼、高度近视、遗传性视网膜疾病、视神经疾病、葡萄膜炎、假性剥脱、玻璃体混浊、视网膜病变、白内障类型、既往手术和后囊破裂。使用马尔可夫链蒙特卡罗(MCMC)方法和弥散先验值拟合屈光结果的多变量正态交叉分类模型,以近似最大似然估计。生成一个具有 5000 次迭代预热和 50000 次监测链的 MCMC 链。
2567 名外科医生为 351864 名患者实施了 490987 例白内障手术。近视和散光误差与后囊破裂(-0.38/+0.04×72)、青光眼(-0.10/+0.05×95)、既往玻璃体切割术(-0.049/+0.03×66)和高度近视(-0.07/+0.03×57)有关。远视和散光误差与糖尿病视网膜病变(+0.08/+0.03×104)、假性剥脱(+0.07/+0.01×158)、男性(+0.12/+0.05×91)和年龄(每增加 10 岁增加 0.01/+0.06×97)有关。遗传性视网膜疾病、视神经疾病、既往小梁切除术、葡萄膜炎、棕褐色/白色白内障对屈光结果的误差没有显著影响。患者性别和合并症的影响是相加的。外科医生仅占屈光结果未解释方差的 4%。
患者的合并症和性别对屈光结果有小但有统计学意义的差异,这种差异是相加的。外科医生的影响很小。