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严重共济失调揭示霍奇金淋巴瘤:寻找隐匿性恶性肿瘤时不要忘记 CT 颈部检查。

Severe ataxia uncovered Hodgkin's lymphoma: do not forget CT neck when looking for covert malignancy.

机构信息

Neurology, King Fahad Medical City, Riyadh, Saudi Arabia

Department of Neurology, Ideal Medicare Clinic, Multan, Punjab, Pakistan.

出版信息

BMJ Case Rep. 2021 Nov 11;14(11):e245225. doi: 10.1136/bcr-2021-245225.

Abstract

A 53-year-old woman without medical problems presented with 5-month history of dizziness, difficulty speaking, severe ataxia, which worsened a day before admission to inability to stand unsupported. An extensive workup was initiated to find the cause of ataxia. The laboratory investigations and imaging of the brain and whole spine revealed no lesions. She was found to have autoimmune thyroiditis, positive coeliac disease antibodies without clinical features and vitamin D deficiency. No intravenous steroids or immunosuppressive therapy was given. Cerebrospinal fluid showed lymphocytic pleocytosis. The workup for the cause of severe ataxia revealed an oropharyngeal lesion with cervical lymph nodes, and the biopsy showed classical Hodgkin's lymphoma of mixed cellularity. She was treated with chemotherapy followed by radiation therapy and made a remarkable recovery, and currently, she is in remission without distant metastases, 5 years after the initial diagnosis. Her neurological status improved, and she remained with mild ataxia.

摘要

一位 53 岁的女性,无医疗问题,出现 5 个月的头晕、言语困难、严重共济失调病史,在入院前一天加重,无法独立站立。进行了广泛的检查以寻找共济失调的原因。实验室检查和脑及全脊柱影像学检查均未见异常。发现患者患有自身免疫性甲状腺炎,抗麦胶蛋白抗体阳性但无临床特征,且存在维生素 D 缺乏。未给予静脉用类固醇或免疫抑制治疗。脑脊液显示淋巴细胞增多。严重共济失调的病因检查显示口咽部有病变并伴有颈部淋巴结,活检显示经典霍奇金淋巴瘤混合细胞型。患者接受了化疗,随后进行了放疗,取得了显著的恢复,目前在初始诊断后 5 年仍处于缓解期,无远处转移。她的神经状态有所改善,仍有轻度共济失调。

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本文引用的文献

1
Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.更新后的副肿瘤性神经系统综合征诊断标准。
Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4). doi: 10.1212/NXI.0000000000001014. Print 2021 Jul.
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Bystander activation and autoimmunity.旁观者激活与自身免疫。
J Autoimmun. 2019 Sep;103:102301. doi: 10.1016/j.jaut.2019.06.012. Epub 2019 Jul 17.
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Spectrum of paraneoplastic disease associated with lymphoma.与淋巴瘤相关的副肿瘤性疾病谱。
Neurology. 2011 Feb 22;76(8):705-10. doi: 10.1212/WNL.0b013e31820d62eb.

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