Marsh W L, Nichols M E, Oyen R, Thayer R S, Deere W L, Freed P J, Schmelter S E
Transfusion. 1978 Mar-Apr;18(2):149-54. doi: 10.1046/j.1537-2995.1978.18278160576.x.
Anti-A and anti-K have been found in the serum of a 20-day-old child who had not been transfused but who was acutely ill with E. coli enterocolitis. Both antibodies are IgM proteins. The mother's serum does not contain either antibody and the anti-A and anti-K in the infant's serum are not of maternal origin. Both parents and the child are of the Kell phenotype K-k+. Stool cultures made from the child yielded E. coli O 125:B15, an uncommon B-variant pathogenic coliform. Cell-free preparations made from broth cultures of this organism have strong specific inhibitory activity against IgM anti-A and anti-K, and both antigens have been identified on the bacterial cells. At age 3 months the child had made a clinical recovery, stool cultures showed no pathogenic coliforms, and anti-A and anti-K were no longer detectable in her serum. These data indicate that absorption of metabolites with A-like and K-like activity produced by a pathogenic coliform in the intestinal tract were responsible for the appearance of apparent naturally occurring anti-A and anti-K in the child's serum.
在一名20日龄、未接受过输血但患有急性大肠杆菌性小肠结肠炎的患儿血清中发现了抗A和抗K抗体。两种抗体均为IgM蛋白。母亲的血清中未含有这两种抗体，婴儿血清中的抗A和抗K并非来自母体。父母和孩子均为Kell血型K-k+表型。患儿的粪便培养物培养出大肠杆菌O 125:B15，这是一种不常见的B型致病性大肠菌群。用该菌株的肉汤培养物制备的无细胞制剂对IgM抗A和抗K具有强烈的特异性抑制活性，且两种抗原均已在细菌细胞上得到鉴定。3个月大时，患儿临床康复，粪便培养物未显示出致病性大肠菌群，其血清中也不再能检测到抗A和抗K。这些数据表明，肠道中致病性大肠菌群产生的具有A样和K样活性的代谢产物的吸收，是导致患儿血清中出现明显自然产生的抗A和抗K的原因。
