Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.
Department of Ophthalmology, Hanyang University Seoul Hospital, 222-1, Wangsimni-ro Seongdong-gu, Seoul, 04763, Korea.
Sci Rep. 2021 Nov 11;11(1):22034. doi: 10.1038/s41598-021-01661-0.
The present study aimed to evaluate the diagnostic ability of wide-field optical coherence tomography angiography (OCTA) density map for detection of glaucomatous damage in high myopic (HM) eyes and to further compare the diagnostic ability of OCTA with that of conventional imaging approaches including red-free photography and swept-source OCT (SS-OCT) wide-field maps. A total of 77 healthy HM eyes and 72 HM eyes with open angle glaucoma (OAG) participated in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT scan and peripapillary area and macular OCTA scans. An integrated OCTA density map thereafter was merged by vascular landmark-guided superimposition of peripapillary and macular superficial vascular density maps onto the red-free photography (resulting in the OCTA-PanoMap). Glaucoma specialists then determined the presence of glaucomatous damage in HM eyes by reading the OCTA-PanoMap and compared its sensitivity and specificity with those of conventional images. Sensitivity and specificity of OCTA-PanoMap for HM-OAG diagnosis was 94.4% and 96.1%, respectively. Compared with other imaging methods, the sensitivity of OCTA-PanoMap was significantly higher than that of red-free photography (P = 0.022) and comparable to that of wide-field SS-OCT maps. Specificity of OCTA-PanoMap was significantly higher than those of other conventional imaging methods (except for wide-field thickness map). The OCTA-PanoMap showed good diagnostic ability for discrimination of HM-OAG eyes from healthy HM eyes. As a complementary method of an alternative imaging modality, OCTA-PanoMap can be a useful tool for detection of HM-OAG.
本研究旨在评估广角光相干断层扫描血管造影（OCTA）密度图在检测高度近视（HM）眼中青光眼损害的诊断能力，并进一步比较 OCTA 与传统成像方法（包括无赤摄影和扫频源 OCT（SS-OCT）广角图）的诊断能力。共有 77 只健康 HM 眼和 72 只 HM 伴开角型青光眼（OAG）眼参与了这项回顾性观察研究。患者接受了全面的眼部检查，包括广角 SS-OCT 扫描以及视盘周围和黄斑 OCTA 扫描。此后，通过血管标志引导的视盘周围和黄斑浅层血管密度图叠加到无赤摄影（产生 OCTA-PanoMap）来融合整合的 OCTA 密度图。青光眼专家随后通过阅读 OCTA-PanoMap 来确定 HM 眼中是否存在青光眼损害，并将其敏感性和特异性与传统图像进行比较。OCTA-PanoMap 用于 HM-OAG 诊断的敏感性和特异性分别为 94.4%和 96.1%。与其他成像方法相比，OCTA-PanoMap 的敏感性明显高于无赤摄影（P=0.022），与广角 SS-OCT 图相当。OCTA-PanoMap 的特异性明显高于其他传统成像方法（除广角厚度图外）。OCTA-PanoMap 对区分 HM-OAG 眼与健康 HM 眼具有良好的诊断能力。作为替代成像方式的补充方法，OCTA-PanoMap 可作为检测 HM-OAG 的有用工具。
