Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
Sci Rep. 2023 Mar 30;13(1):5209. doi: 10.1038/s41598-023-32164-9.
Macular OCT angiography (OCTA) measurements have been reported to be useful for glaucoma diagnostics. However, research on highly myopic glaucoma is lacking, and the diagnostic value of macular OCTA measurements versus OCT parameters remains inconclusive. We aimed to evaluate the diagnostic ability of the macular microvasculature assessed with OCTA for highly myopic glaucoma and to compare it with that of macular thickness parameters, using deep learning (DL). A DL model was trained, validated and tested using 260 pairs of macular OCTA and OCT images from 260 eyes (203 eyes with highly myopic glaucoma, 57 eyes with healthy high myopia). The DL model achieved an AUC of 0.946 with the OCTA superficial capillary plexus (SCP) images, which was comparable to that with the OCT GCL+ (ganglion cell layer + inner plexiform layer; AUC, 0.982; P = 0.268) or OCT GCL++ (retinal nerve fiber layer + ganglion cell layer + inner plexiform layer) images (AUC, 0.997; P = 0.101), and significantly superior to that with the OCTA deep capillary plexus images (AUC, 0.779; P = 0.028). The DL model with macular OCTA SCP images demonstrated excellent and comparable diagnostic ability to that with macular OCT images in highly myopic glaucoma, which suggests macular OCTA microvasculature could serve as a potential biomarker for glaucoma diagnosis in high myopia.
黄斑 OCT 血管造影（OCTA）测量值已被证明可用于青光眼的诊断。然而，对于高度近视性青光眼的研究较少，OCTA 测量值与 OCT 参数的诊断价值仍不确定。我们旨在使用深度学习（DL）评估 OCTA 评估的黄斑微血管对高度近视性青光眼的诊断能力，并将其与黄斑厚度参数进行比较。使用来自 260 只眼睛（203 只高度近视性青光眼，57 只健康高度近视）的 260 对黄斑 OCTA 和 OCT 图像，训练、验证和测试了一个 DL 模型。DL 模型使用 OCTA 浅层毛细血管丛（SCP）图像的 AUC 为 0.946，与 OCT GCL+（神经节细胞层+内丛状层；AUC，0.982；P=0.268）或 OCT GCL++（视网膜神经纤维层+神经节细胞层+内丛状层；AUC，0.997；P=0.101）图像相当，并且明显优于 OCTA 深层毛细血管丛图像（AUC，0.779；P=0.028）。黄斑 OCTA SCP 图像的 DL 模型在高度近视性青光眼的诊断能力方面表现出出色且相当的能力，这表明黄斑 OCTA 微血管可作为高度近视性青光眼诊断的潜在生物标志物。
