升级三羧酸循环——重塑肿瘤相关成纤维细胞
Upcycling the TCA cycle-rewiring tumour-associated fibroblasts.
作者信息
Bacigalupa Zachary A, Rathmell W Kimryn
机构信息
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Nat Metab. 2021 Nov;3(11):1439-1440. doi: 10.1038/s42255-021-00473-w.
Abstract
Alterations to the extracellular matrix have long been associated with cancer progression and therapeutic resistance. Schwörer et al. describe a mechanism whereby fibroblasts reroute metabolites to fuel the demands of collagen synthesis, leading to cancer progression.
摘要
细胞外基质的改变长期以来一直与癌症进展和治疗耐药性相关。施沃勒等人描述了一种机制，即成纤维细胞重新定向代谢物以满足胶原蛋白合成的需求，从而导致癌症进展。
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