• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Upcycling the TCA cycle-rewiring tumour-associated fibroblasts.升级三羧酸循环——重塑肿瘤相关成纤维细胞
Nat Metab. 2021 Nov;3(11):1439-1440. doi: 10.1038/s42255-021-00473-w.
2
TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma.三羧酸循环重编程作为肝细胞癌新出现的代谢特征
Cancers (Basel). 2019 Dec 25;12(1):68. doi: 10.3390/cancers12010068.
3
TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans.三羧酸循环重编程促进了啮齿动物和人类骨骼肌对氧限制的代谢适应。
Sci Rep. 2017 Aug 29;7(1):9723. doi: 10.1038/s41598-017-10097-4.
4
Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts.化学再生创面缺陷：与犬腭裂黏膜和人牙龈成纤维细胞细胞周期上调的相关性。
Tissue Eng Regen Med. 2019 Nov 21;16(6):675-684. doi: 10.1007/s13770-019-00227-6. eCollection 2019 Dec.
5
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.三羧酸循环的破坏揭示了 ATF4 依赖性的氧化还原和氨基酸代谢的整合。
Elife. 2021 Dec 23;10:e72593. doi: 10.7554/eLife.72593.
6
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis.RNA 结合蛋白及其相关的长非编码 RNA 在 TCA 循环中对癌症发病机制的影响。
RNA Biol. 2023 Jan;20(1):223-234. doi: 10.1080/15476286.2023.2216562.
7
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.缺氧黑色素瘤细胞的脂肪生成需要异柠檬酸脱氢酶 1 和 2 进行反向三羧酸循环通量。
Pigment Cell Melanoma Res. 2012 May;25(3):375-83. doi: 10.1111/j.1755-148X.2012.00989.x. Epub 2012 Mar 27.
8
Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts.成纤维细胞中丙酮酸脱氢酶失活的代谢和致癌适应。
J Biol Chem. 2019 Apr 5;294(14):5466-5486. doi: 10.1074/jbc.RA118.005200. Epub 2019 Feb 12.
9
Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii.弓形虫中糖异生和三羧酸（TCA）循环酶的定位及TCA循环的首次功能分析
Int J Parasitol. 2008 Aug;38(10):1121-32. doi: 10.1016/j.ijpara.2008.01.007. Epub 2008 Feb 13.
10
TCA cycle off, ATF4 on for metabolic homeostasis.三羧酸循环关闭，ATF4 开启以维持代谢平衡。
Trends Biochem Sci. 2022 Jul;47(7):558-560. doi: 10.1016/j.tibs.2022.03.006. Epub 2022 Mar 12.

引用本文的文献

1
Targeting the ANXA8-SP1-PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer.靶向ANXA8-SP1-PPA1轴调节弥漫型胃癌中的三羧酸循环和基质沉积
Research (Wash D C). 2025 Aug 25;8:0838. doi: 10.34133/research.0838. eCollection 2025.
2
The facilitated osteogenic differentiation by extracellular proline treatment in in vitro cell cultivation using MC3T3E1 and hPDLF.在使用MC3T3E1和人牙周膜成纤维细胞（hPDLF）的体外细胞培养中，细胞外脯氨酸处理促进成骨分化。
Genes Genomics. 2025 Feb;47(2):157-169. doi: 10.1007/s13258-024-01588-6. Epub 2024 Nov 20.

本文引用的文献

1
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment.成纤维细胞丙酮酸羧化酶是肿瘤微环境中胶原蛋白产生所必需的。
Nat Metab. 2021 Nov;3(11):1484-1499. doi: 10.1038/s42255-021-00480-x. Epub 2021 Nov 11.
2
Mitochondrial NADP(H) generation is essential for proline biosynthesis.线粒体 NADP(H) 的产生对于脯氨酸生物合成至关重要。
Science. 2021 May 28;372(6545):968-972. doi: 10.1126/science.abd5491. Epub 2021 Apr 22.
3
Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress.脯氨酸生物合成是 TGFβ 诱导的线粒体氧化还原应激的出路。
EMBO J. 2020 Apr 15;39(8):e103334. doi: 10.15252/embj.2019103334. Epub 2020 Mar 5.
4
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.谷氨酰胺代谢是肺成纤维细胞胶原蛋白合成所必需的。
Am J Respir Cell Mol Biol. 2019 Nov;61(5):597-606. doi: 10.1165/rcmb.2019-0008OC.
5
Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment.细胞外基质胶原 I 促进热疗后残余肝细胞癌的肿瘤进展。
BMC Cancer. 2018 Sep 18;18(1):901. doi: 10.1186/s12885-018-4820-9.
6
Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.谷氨酰胺分解代谢对于转化生长因子-β1 诱导的肌成纤维细胞分化和激活是必需的。
J Biol Chem. 2018 Jan 26;293(4):1218-1228. doi: 10.1074/jbc.RA117.000444. Epub 2017 Dec 8.
7
The biology and function of fibroblasts in cancer.成纤维细胞在癌症中的生物学和功能。
Nat Rev Cancer. 2016 Aug 23;16(9):582-98. doi: 10.1038/nrc.2016.73.
8
The extracellular matrix in development and morphogenesis: a dynamic view.发育和形态发生中的细胞外基质：动态观点。
Dev Biol. 2010 May 1;341(1):126-40. doi: 10.1016/j.ydbio.2009.10.026. Epub 2009 Oct 23.
9
Fibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro.
Lancet. 1984 Oct 20;2(8408):890-2. doi: 10.1016/s0140-6736(84)90653-6.
10
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.转化生长因子-β刺激纤连蛋白和胶原蛋白的表达，并促使它们整合到细胞外基质中。
J Biol Chem. 1986 Mar 25;261(9):4337-45.

升级三羧酸循环——重塑肿瘤相关成纤维细胞

Upcycling the TCA cycle-rewiring tumour-associated fibroblasts.

作者信息

Bacigalupa Zachary A, Rathmell W Kimryn

机构信息

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

出版信息

Nat Metab. 2021 Nov;3(11):1439-1440. doi: 10.1038/s42255-021-00473-w.

DOI:10.1038/s42255-021-00473-w
PMID:34764458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9383054/
Abstract

Alterations to the extracellular matrix have long been associated with cancer progression and therapeutic resistance. Schwörer et al. describe a mechanism whereby fibroblasts reroute metabolites to fuel the demands of collagen synthesis, leading to cancer progression.

摘要

细胞外基质的改变长期以来一直与癌症进展和治疗耐药性相关。施沃勒等人描述了一种机制，即成纤维细胞重新定向代谢物以满足胶原蛋白合成的需求，从而导致癌症进展。