RNA 结合蛋白及其相关的长非编码 RNA 在 TCA 循环中对癌症发病机制的影响。

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis.

机构信息

Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, Anhui Provincial Engineering Research Centre for Molecular Detection and Diagnostics, College of Life Sciences, Anhui Normal University, Wuhu, China.

Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.

出版信息

RNA Biol. 2023 Jan;20(1):223-234. doi: 10.1080/15476286.2023.2216562.

DOI:10.1080/15476286.2023.2216562

PMID:37221841

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10210855/

Abstract

The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated in various tumour pathological processes. Interestingly, several TCA enzymes exhibit the characteristics of RNA binding properties, and their long non-coding RNA (lncRNA) partners play critical regulatory roles in regulating the function of TCA cycle and tumour progression. In this review, we will discuss the functional roles of RNA binding proteins and their lncRNA partners in TCA cycle, with emphasis placed on the cancer progression. A further understanding of RNA binding proteins and their lncRNA partners in TCA cycle, as well as their molecular mechanisms in oncogenesis, will aid in developing novel layers of metabolic targets for cancer therapy in the near future. CS: citrate synthase. AH: aconitase, including ACO1, and ACO2. IDH: isocitrate dehydrogenase, including IDH1, IDH2, and IDH3. KGDHC: α-ketoglutarate dehydrogenase complex, including OGDH, DLD, and DLST. SCS: succinyl-CoA synthase, including SUCLG1, SUCLG2, and SUCLA2. SDH: succinate dehydrogenase, including SDHA, SDHB, SDHC, and SDHD. FH: fumarate hydratase. MDH: malate dehydrogenase, including MDH1 and MDH2. PC: pyruvate carboxylase. ACLY: ATP Citrate Lyase. NIT: nitrilase. GAD: glutamate decarboxylase. ABAT: 4-aminobutyrate aminotransferase. ALDH5A1: aldehyde dehydrogenase 5 family member A1. ASS: argininosuccinate synthase. ASL: adenylosuccinate synthase. DDO: D-aspartate oxidase. GOT: glutamic-oxaloacetic transaminase. GLUD: glutamate dehydrogenase. HK: hexokinase. PK: pyruvate kinase. LDH: lactate dehydrogenase. PDK: pyruvate dehydrogenase kinase. PDH: pyruvate dehydrogenase complex. PHD: prolyl hydroxylase domain protein.

摘要

三羧酸 (TCA) 循环是生成细胞能量和生物合成途径前体的中心途径。新出现的证据表明，影响 TCA 循环完整性的代谢酶的异常与各种肿瘤病理过程有关。有趣的是，几种 TCA 酶表现出 RNA 结合特性，其长链非编码 RNA (lncRNA) 伴侣在调节 TCA 循环和肿瘤进展的功能中发挥关键调节作用。在这篇综述中，我们将讨论 RNA 结合蛋白及其 TCA 循环中的 lncRNA 伴侣的功能作用，重点是癌症进展。进一步了解 TCA 循环中的 RNA 结合蛋白及其 lncRNA 伴侣及其在致癌中的分子机制，将有助于在不久的将来为癌症治疗开发新的代谢靶点。CS：柠檬酸合酶。AH：顺乌头酸酶，包括 ACO1 和 ACO2。IDH：异柠檬酸脱氢酶，包括 IDH1、IDH2 和 IDH3。KGDHC：α-酮戊二酸脱氢酶复合物，包括 OGDH、DLD 和 DLST。SCS：琥珀酰-CoA 合酶，包括 SUCLG1、SUCLG2 和 SUCLA2。SDH：琥珀酸脱氢酶，包括 SDHA、SDHB、SDHC 和 SDHD。FH：延胡索酸水合酶。MDH：苹果酸脱氢酶，包括 MDH1 和 MDH2。PC：丙酮酸羧化酶。ACLY：ATP 柠檬酸裂解酶。NIT：腈水解酶。GAD：谷氨酸脱羧酶。ABAT：4-氨基丁酸转氨酶。ALDH5A1：醛脱氢酶 5 家族成员 A1。ASS：精氨琥珀酸合成酶。ASL：腺嘌呤核苷琥珀酸合成酶。DDO：D-天冬氨酸氧化酶。GOT：谷草转氨酶。GLUD：谷氨酸脱氢酶。HK：己糖激酶。PK：丙酮酸激酶。LDH：乳酸脱氢酶。PDK：丙酮酸脱氢酶激酶。PDH：丙酮酸脱氢酶复合物。PHD：脯氨酰羟化酶结构域蛋白。