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RAB11FIP1：基于生物信息学综合分析的肺腺癌肿瘤免疫微环境及预后指标

RAB11FIP1: An Indicator for Tumor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics.

作者信息

Zhang Wenyi, Chen Ting, Liu Jun, Yu Shali, Liu Lei, Zheng Miaosen, Liu Yifei, Zhang Hongbing, Bian Tingting, Zhao Xinyuan

机构信息

School of Public Health, Nantong University, Nantong, China.

Department of Pathology, Affiliated Dongtai Hospital of Nantong University, Dongtai, China.

出版信息

Front Genet. 2021 Oct 26;12:757169. doi: 10.3389/fgene.2021.757169. eCollection 2021.

DOI:10.3389/fgene.2021.757169
PMID:34764984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8576257/
Abstract

Lung adenocarcinoma (LUAD) was the first one all over the world. RAB11FIP1 was found to be expressed differently in a critical way among different cancers. However, the prognostic value and immune infiltration of RAB11FIP1 expression in LUAD are unclear. In this study, the expression of RAB11FIP1 in LUAD was investigated in the Oncomine, TCGA, GEO, and UALCAN databases. Kaplan-Meier analysis was chosen to compare the association between RAB11FIP1 expression and overall survival (OS) in LUAD patients. The dataset of TCGA was used to analyze the pertinence between RAB11FIP1 and clinicpathological factors. GO, KEGG, and network analysis of protein-protein interactions (PPI) were conducted to investigate the potential mechanism of RAB11FIP1. In the end, the relevance of RAB11FIP1 to cancer-immune infiltrates was investigated. RAB11FIP1 was found to be down-regulated by tumors compared with adjacent normal tissue in multiple LUAD cohorts. RAB11FIP1 is an independent prognostic factor in lung adenocarcinoma. There was a high correlation between low RAB11FIP1 in tumors and worse OS in LUAD. Functional network analysis suggested that RAB11FIP1 was associated with multiple pathways. Besides, the expression of RAB11FIP1 was closely related to the infiltration levels of B cell, CD8 T cells, CD4 T cells, macrophages, neutrophils, and dendritic cells. RAB11FIP1 expression in LUAD occurred with a variety of immune markers. Our findings suggest that RAB11FIP1 is related to prognosis and immune infiltrates in LUAD.

摘要

肺腺癌（LUAD）在全球范围内位列第一。研究发现RAB11FIP1在不同癌症中存在显著差异表达。然而，RAB11FIP1在LUAD中的预后价值和免疫浸润情况尚不清楚。在本研究中，通过Oncomine、TCGA、GEO和UALCAN数据库对LUAD中RAB11FIP1的表达进行了研究。采用Kaplan-Meier分析比较RAB11FIP1表达与LUAD患者总生存期（OS）之间的关联。利用TCGA数据集分析RAB11FIP1与临床病理因素之间的相关性。进行基因本体（GO）、京都基因与基因组百科全书（KEGG）以及蛋白质-蛋白质相互作用（PPI）网络分析，以探究RAB11FIP1的潜在机制。最后，研究了RAB11FIP1与癌症免疫浸润的相关性。在多个LUAD队列中发现，与相邻正常组织相比，肿瘤组织中RAB11FIP1表达下调。RAB11FIP1是肺腺癌的独立预后因素。肿瘤中低表达的RAB11FIP1与LUAD患者较差的总生存期密切相关。功能网络分析表明，RAB11FIP1与多种信号通路相关。此外，RAB11FIP1的表达与B细胞、CD8 T细胞、CD4 T细胞、巨噬细胞、中性粒细胞和树突状细胞的浸润水平密切相关。LUAD中RAB11FIP1的表达与多种免疫标志物有关。我们的研究结果表明，RAB11FIP1与LUAD的预后和免疫浸润相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/32527da41d55/fgene-12-757169-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/afcd0c92c60f/fgene-12-757169-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/0093ddaaa6e3/fgene-12-757169-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/32527da41d55/fgene-12-757169-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/afcd0c92c60f/fgene-12-757169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/546a6e591fbf/fgene-12-757169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/3398ec05647c/fgene-12-757169-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/8bda17e50dc8/fgene-12-757169-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/ff52963ab071/fgene-12-757169-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/0093ddaaa6e3/fgene-12-757169-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eefa/8576257/32527da41d55/fgene-12-757169-g008.jpg

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