Lindskog S, Blomlöf L, Hammarström L
J Clin Periodontol. 1987 Aug;14(7):390-5. doi: 10.1111/j.1600-051x.1987.tb01542.x.
Cellular colonization of denuded root surfaces on replanted teeth was examined with scanning electron microscopy. The dentin surface was rapidly colonized by a few macrophage-like cells which resorbed dentin in limited areas. They had well-developed ruffled borders but no clear zones. The resorptive activity was gradually inhibited by the ingrowth of a monolayer of fibroblast-like cells from the periphery of the denuded area. At the advancing front, the ingrowing fibroblast-like cells were long and slender, with long tail-like projections trailing the nuclear domain. The invading cells behind these were well-spread and tightly packed. They had a granulated surface and showed morphological signs of fibre synthesis. After 6 weeks, the entire cavity was covered by a monolayer of these cells. Removal of the cells with sodium hypochlorite revealed that a cementum-like tissue had been formed under the invading cells, indicating that they were cementoblasts. It was concluded that wound repair on the root surface is dependent upon the differentiation and proliferation of pre-cementoblasts in the periphery of the wound and that cells in the main body of the periodontal membrane are of little significance in the healing process on the root surface.
用扫描电子显微镜检查再植牙裸露根面的细胞定植情况。牙本质表面迅速被一些巨噬细胞样细胞定植，这些细胞在有限区域吸收牙本质。它们有发育良好的皱褶缘，但没有透明区。随着单层成纤维细胞样细胞从裸露区域周边向内生长，吸收活性逐渐受到抑制。在生长前沿，向内生长的成纤维细胞样细胞长而细长，核区后方有长长的尾状突起。这些细胞后面的侵入细胞铺展良好且紧密排列。它们表面有颗粒，显示出纤维合成的形态学迹象。6周后，整个窝洞被这些细胞的单层覆盖。用次氯酸钠去除细胞后发现，在侵入细胞下方形成了类似牙骨质的组织，表明它们是成牙骨质细胞。得出的结论是，根面的伤口修复依赖于伤口周边前成牙骨质细胞的分化和增殖，并且牙周膜主体中的细胞在根面愈合过程中意义不大。
