可变剪接在人类癌症进展中的作用。
The role of alternative splicing in human cancer progression.
作者信息
Ouyang Jiawei, Zhang Yijie, Xiong Fang, Zhang Shanshan, Gong Zhaojian, Yan Qijia, He Yi, Wei Fang, Zhang Wenling, Zhou Ming, Xiang Bo, Wang Fuyan, Li Xiaoling, Li Yong, Li Guiyuan, Zeng Zhaoyang, Guo Can, Xiong Wei
机构信息
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, Hunan, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of The Chinese Ministry of Education, Cancer Research Institute, Central South University Changsha 410078, Hunan, China.
出版信息
Am J Cancer Res. 2021 Oct 15;11(10):4642-4667. eCollection 2021.
In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer.
在真核生物中，可变剪接是指单个前体RNA（pre-RNA）被转录成不同成熟RNA的过程。因此，可变剪接使得有限数量的编码基因能够翻译出大量具有不同功能的蛋白质。虽然可变剪接在正常细胞中很常见，但它在癌症发展中也起着重要作用。剪接机制的改变甚至非编码RNA的参与都可能导致癌症相关基因剪接模式的变化。本文综述了癌症中可变剪接的最新研究，以期提出新策略并指导与癌症相关病理机制的未来研究。
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