Hellwig E, Klimek J, Wagner H
J Dent Res. 1987 Jan;66(1):46-9. doi: 10.1177/00220345870660011001.
A modified Intra-oral Cariogenicity Test was used to study the influence of plaque on the reaction mechanism of sodium monofluorophosphate (MFP) or sodium fluoride (NaF) in either sound or demineralized enamel in vivo. Volunteer students, wearing mouth appliances holding enamel blocks, rinsed their mouths with MFP or NaF solution (1,000 ppm F-) three times a day. The amount of loosely-bound and acquired fluoride was determined after an experimental period of five days in plaque-covered, demineralized (PCD); clean, demineralized (CD); plaque-covered, sound (PCS); and clean sound enamel (CS). While no measurable loosely-bound fluoride could be found after MFP treatment, NaF caused deposition of a significant amount of alkali-soluble fluoride in all experimental groups. After MFP rinses, fluoride concentration in the enamel was increased in the following order: CS, PCS, CD, and PCD. After NaF treatment, demineralized enamel exhibited a higher fluoride acquisition when compared with sound enamel. Plaque had a minor effect on F- acquisition. It is concluded that demineralization of enamel enhances F- uptake from both NaF and MFP solutions. In the presence of plaque, F- acquisition was additionally increased only after MFP rinses in vivo.
采用改良的口腔内致龋性试验，研究菌斑对单氟磷酸钠（MFP）或氟化钠（NaF）在体内健全或脱矿釉质中反应机制的影响。佩戴装有釉质块的口腔矫治器的志愿者学生，每天用MFP或NaF溶液（1000 ppm F-）漱口三次。在为期五天的实验期后，测定菌斑覆盖的脱矿（PCD）、清洁的脱矿（CD）、菌斑覆盖的健全（PCS）和清洁的健全釉质（CS）中松散结合和获得性氟化物的量。MFP处理后未发现可测量的松散结合氟化物，而NaF在所有实验组中均导致大量碱溶性氟化物沉积。MFP漱口后，釉质中的氟浓度按以下顺序增加：CS、PCS、CD和PCD。NaF处理后，与健全釉质相比，脱矿釉质表现出更高的氟摄取量。菌斑对氟摄取的影响较小。结论是釉质脱矿增强了从NaF和MFP溶液中的氟摄取。在有菌斑的情况下，仅在体内MFP漱口后氟摄取量才会额外增加。
