局限性前列腺癌聚焦治疗的未来展望。
Future perspective of focal therapy for localized prostate cancer.
作者信息
O'Connor Luke P, Ramedani Shayann, Daneshvar Michael, George Arvin K, Abreu Andre Luis, Cacciamani Giovanni E, Lebastchi Amir H
机构信息
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
出版信息
Asian J Urol. 2021 Oct;8(4):354-361. doi: 10.1016/j.ajur.2021.04.011. Epub 2021 May 3.
OBJECTIVE
To summarize the recent literature discussing focal therapy for localized prostate cancer.
METHODS
A thorough literature review was performed using PubMed to identify recent studies involving focal therapy for the treatment of localized prostate cancer.
RESULTS
In an effort to decrease the morbidity associated with prostate cancer treatment, many urologists are turning to focal therapy as an alternative treatment option. With this approach, the cancer bearing portion of the prostate is targeted while leaving the benign tissue untouched. Multiparametric magnetic resonance imaging remains the gold standard for visualization during focal therapy, but new imaging modalities such as prostate specific membrane antigen/positron emission tomography and contrast enhanced ultrasound are being investigated. Furthermore, several biomarkers, such as prostate cancer antigen 3 and prostate health index, are used in conjunction with imaging to improve risk stratification prior to focal therapy. Lastly, there are several novel technologies such as nanoparticles and transurethral devices that are under investigation for use in focal therapy.
CONCLUSION
Focal therapy is proving to be a promising option for the treatment of localized prostate cancer. However, further study is needed to determine the true efficacy of these exciting new technologies.
目的
总结近期讨论局限性前列腺癌聚焦治疗的文献。
方法
使用PubMed进行全面的文献综述，以识别近期涉及局限性前列腺癌聚焦治疗的研究。
结果
为了降低与前列腺癌治疗相关的发病率，许多泌尿科医生正在转向聚焦治疗作为一种替代治疗选择。采用这种方法时，前列腺的癌组织部分成为靶点，而良性组织则保持未受影响。多参数磁共振成像仍然是聚焦治疗期间可视化的金标准，但诸如前列腺特异性膜抗原/正电子发射断层扫描和超声造影等新的成像模式正在研究中。此外，几种生物标志物，如前列腺癌抗原3和前列腺健康指数，与成像结合使用，以改善聚焦治疗前的风险分层。最后，有几种新技术，如纳米颗粒和经尿道装置，正在研究用于聚焦治疗。
结论
聚焦治疗被证明是治疗局限性前列腺癌的一个有前景的选择。然而，需要进一步研究以确定这些令人兴奋的新技术的真正疗效。
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