Systematic Analysis of the Clinical Significance of Hyaluronan-Mediated Motility Receptor in Colorectal Cancer.

The role of hyaluronan-mediated motility receptor () in colorectal cancer (CRC) remains unclear. The present study aimed to explore the association of with the development and prognosis of CRC using sequence datasets, clinical tissues, blood samples, and cell lines. CRC datasets were downloaded from TCGA and GEO databases. Forty CRC tissue samples, 120 CRC blood samples, and 100 healthy controls were collected. Four CRC cell lines (HCT116, HT-29, LoVo, and SW480) and one normal human colon mucosal epithelial cell line (NCM460) were cultured. RT-qPCR was used to determine the expression of in the tissues and cell lines. ELISA was used to measure levels in the blood samples. The expression of was significantly increased in CRC tissues than in corresponding adjacent tissues based on TCGA and GEO datasets, and clinical CRC tissues. No associations were found between the expression of and the TNM stage or other clinical parameters. The expression of varied in different CRC cell lines. The blood levels of tended to be higher in patients with CRC than in healthy controls. TCGA and GEO datasets showed inconsistent results regarding the association of expression with the survival of patients with CRC. The expression of is increased in CRC tissues but not in the blood. The expression of is independent of CRC development and has no prognostic significance in patients with CRC.