Caslavska V, Gron P, Kent R
J Dent Res. 1987 Jun;66(6):1159-61. doi: 10.1177/00220345870660061301.
The purpose of this animal investigation was to determine whether the cariostatic effect of sodium fluoride can be enhanced by combining it with certain surfactants. The surfactants, Zonyl FSC and Lodyne S-110, were selected because they had been found to accelerate the rate of deposition of firmly-bound fluoride in vitro in enamel during enamel-fluoride interaction. Sixty male hamsters and 60 female rats, 21 days old, were placed on the high-sucrose diet 2000 and inoculated with Streptococcus mutans (strain #6715). Each set of animals was divided into six groups of 10 each. The groups received either distilled water, NaF, NaF with Lodyne S-110, NaF with Zonyl FSC, Lodyne S-110, or Zonyl FSC. The animals were scored for caries at the termination of the study. The caries findings in the hamster and the rat series closely paralleled each other. Animals receiving NaF with Zonyl FSC experienced the least decay (about 90% inhibition compared with about 65% for the NaF-alone group). A statistical evaluation showed significant interaction between Zonyl FSC and NaF. No effect on caries experience was seen from administration of Lodyne S-110.
本动物研究的目的是确定将氟化钠与某些表面活性剂结合使用是否能增强其防龋效果。选择表面活性剂Zonyl FSC和Lodyne S - 110，是因为它们在体外牙釉质与氟相互作用过程中能加速紧密结合氟在牙釉质中的沉积速率。选用60只21日龄的雄性仓鼠和60只21日龄的雌性大鼠，给它们喂食高糖饮食2000，并接种变形链球菌（菌株#6715）。每组动物分为6组，每组10只。这些组分别接受蒸馏水、氟化钠、含Lodyne S - 110的氟化钠、含Zonyl FSC的氟化钠、Lodyne S - 110或Zonyl FSC。在研究结束时对动物的龋齿情况进行评分。仓鼠组和大鼠组的龋齿研究结果非常相似。接受含Zonyl FSC的氟化钠的动物龋齿情况最少（与单独使用氟化钠组约65%的抑制率相比，抑制率约为90%）。统计评估显示Zonyl FSC和氟化钠之间存在显著的相互作用。施用Lodyne S - 110对龋齿情况没有影响。
