Kapoor Sahil, Singh Meenakshi, Srivastava Atul, Chavali Murthy, Chandrasekhar K, Verma Pradeep
Department of Botany, MS University of Baroda, Vadodara, Gujarat, India.
Department of Botany, Goswami Ganesh Dutta S.D. College, Chandigarh, India.
J Basic Microbiol. 2022 Sep;62(9):1044-1063. doi: 10.1002/jobm.202100458. Epub 2021 Nov 12.
Microalgae are regarded as a rich trove of diverse secondary metabolites that exert remarkable biological activities. In particular, microalgae-derived bioactive phenolic compounds (MBPCs) are a boon to biopharmaceutical and nutraceutical industries due to their diverse bioactivities, including antimicrobial, anticancer, antiviral, and immunomodulatory activities. The state-of-the-art green technologies for extraction and purification of MBPCs, along with the modern progress in the identification and characterization of MBPCs, have accelerated the discovery of novel active pharmaceutical compounds. However, several factors regulate the production of these bioactive phenolic compounds in microalgae. Furthermore, some microalgae species produce toxic phenolic compounds that negatively impact the aquatic ecosystem, animal, and human life. Therefore, the focus of this review paper is to bring into light the current innovations in bioprospection, extraction, purification, and characterization of MBPCs. This review is also aimed at a better understanding of the physicochemical factors regulating the production of MBPCs at an industrial scale. Finally, the present review covers the recent advances in toxicological evaluation, diverse applications, and future prospects of MBPCs in biopharmaceutical industries.
微藻被视为多种具有显著生物活性的次生代谢产物的丰富宝库。特别是，微藻衍生的生物活性酚类化合物（MBPCs）因其多样的生物活性，包括抗菌、抗癌、抗病毒和免疫调节活性，对生物制药和营养保健品行业来说是一大福音。用于提取和纯化MBPCs的先进绿色技术，以及MBPCs鉴定和表征方面的现代进展，加速了新型活性药物化合物的发现。然而，有几个因素调节微藻中这些生物活性酚类化合物的产生。此外，一些微藻物种会产生对水生生态系统、动物和人类生活有负面影响的有毒酚类化合物。因此，本综述文章的重点是揭示MBPCs生物勘探、提取、纯化和表征方面的当前创新。本综述还旨在更好地理解在工业规模上调节MBPCs产生的物理化学因素。最后，本综述涵盖了MBPCs在生物制药行业毒理学评价、多样应用和未来前景方面的最新进展。
