Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Nutrients. 2022 Aug 17;14(16):3383. doi: 10.3390/nu14163383.
Inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) are common diseases of the digestive system. Vitamin deficiencies and gut microbiota dysbiosis have a close relationship with the risk, development, and progression of IBD and CAC. There is a strong link between vitamins and the gut microbiome. Vitamins are extremely crucial for maintaining a healthy gut microbiota, promoting growth and development, metabolism, and innate immunity. Gut microbiota can not only influence the transport process of vitamins, but also produce vitamins to compensate for insufficient food intake. Emerging evidence suggests that oral vitamin supplementation can reduce inflammation levels and improve disease prognosis. In addition, improving the diet structure and consuming foods rich in vitamins not only help to improve the vitamin deficiency, but also help to reduce the risk of IBD. Fecal microbiota transplantation (FMT) and the application of vitamin-producing probiotics can better assist in the treatment of intestinal diseases. In this review, we discuss the interaction and therapeutic roles of vitamins and gut microbiota in IBD and CAC. We also summarize the methods of treating IBD and CAC by modulating vitamins. This may highlight strategies to target gut-microbiota-dependent alterations in vitamin metabolism in the context of IBD and CAC therapy.
炎症性肠病（IBD）和结肠炎相关结直肠癌（CAC）是常见的消化系统疾病。维生素缺乏和肠道微生物失调与 IBD 和 CAC 的风险、发展和进展密切相关。维生素和肠道微生物组之间存在很强的联系。维生素对维持健康的肠道微生物群、促进生长发育、新陈代谢和先天免疫至关重要。肠道微生物群不仅可以影响维生素的转运过程，还可以产生维生素来弥补食物摄入的不足。新出现的证据表明，口服维生素补充剂可以降低炎症水平并改善疾病预后。此外，改善饮食结构和摄入富含维生素的食物不仅有助于改善维生素缺乏，还有助于降低 IBD 的风险。粪便微生物群移植（FMT）和应用产维生素益生菌可以更好地辅助肠道疾病的治疗。在这篇综述中，我们讨论了维生素和肠道微生物群在 IBD 和 CAC 中的相互作用和治疗作用。我们还总结了通过调节维生素来治疗 IBD 和 CAC 的方法。这可能突出了在 IBD 和 CAC 治疗中针对维生素代谢的肠道微生物群依赖性改变的策略。
