Department of Biochemistry, University of Toronto, 661 University Ave, Toronto, ON, Canada.
Cell. 2021 Nov 11;184(23):5691-5693. doi: 10.1016/j.cell.2021.10.012.
Cyclic pyrimidines cCMP and cUMP were known to be present in a variety of organisms and cell types, but their biological roles remained mysterious. Tal et al. show that bacteria use cCMP and cUMP as second messengers that function in anti-phage defense.
环化嘧啶核苷酸 cCMP 和 cUMP 已知存在于多种生物体和细胞类型中，但它们的生物学功能仍然神秘。Tal 等人表明，细菌将 cCMP 和 cUMP 用作在抗噬菌体防御中发挥作用的第二信使。
