代谢综合征与感音神经性听力损失的关联
Association of Metabolic Syndrome with Sensorineural Hearing Loss.
作者信息
Rim Hwa-Sung, Kim Myung-Gu, Park Dong-Choon, Kim Sung-Soo, Kang Dae-Woong, Kim Sang-Hoon, Yeo Seung-Geun
机构信息
Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02454, Korea.
Department of Otorhinolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Korea.
出版信息
J Clin Med. 2021 Oct 22;10(21):4866. doi: 10.3390/jcm10214866.
UNLABELLED
The prevalence of sensorineural hearing loss has increased along with increases in life expectancy and exposure to noisy environments. Metabolic syndrome (MetS) is a cluster of co-occurring conditions that increase the risk of heart disease, stroke and type 2 diabetes, along with other conditions that affect the blood vessels. Components of MetS include insulin resistance, body weight, lipid concentration, blood pressure, and blood glucose concentration, as well as other features of insulin resistance such as microalbuminuria. MetS has become a major public health problem affecting 20-30% of the global population. This study utilized health examination to investigate whether metabolic syndrome was related to hearing loss.
METHODS
A total of 94,223 people who underwent health check-ups, including hearing tests, from January 2010 to December 2020 were evaluated. Subjects were divided into two groups, with and without metabolic syndrome. In addition, Scopus, Embase, PubMed, and Cochrane libraries were systematically searched, using keywords such as "hearing loss" and "metabolic syndrome", for studies that evaluated the relationship between the two.
RESULTS
Of the 94,223 subjects, 11,414 (12.1%) had metabolic syndrome and 82,809 did not. The mean ages of subjects in the two groups were 46.1 and 43.9 years, respectively. A comparison of hearing thresholds by age in subjects with and without metabolic syndrome showed that the average pure tone hearing thresholds were significantly higher in subjects with metabolic syndrome than in subjects without it in all age groups. ( < 0.001) Rates of hearing loss in subjects with 0, 1, 2, 3, 4, and 5 of the components of metabolic syndrome were 7.9%, 12.1%, 13.8%, 13.8%, 15.5% and 16.3%, respectively, indicating a significant association between the number of components of metabolic syndrome and the rate of hearing loss ( < 0.0001). The odds ratio of hearing loss was significantly higher in subjects with four components of metabolic syndrome: waist circumference, blood pressure, and triglyceride and fasting blood sugar concentrations ( < 0.0001).
CONCLUSIONS
The number of components of the metabolic syndrome is positively correlated with the rate of sensorineural hearing loss.
未标注
随着预期寿命的延长以及暴露于嘈杂环境中的情况增多，感音神经性听力损失的患病率有所上升。代谢综合征（MetS）是一组同时出现的病症，会增加患心脏病、中风和2型糖尿病的风险，以及影响血管的其他病症。MetS的组成部分包括胰岛素抵抗、体重、血脂浓度、血压和血糖浓度，以及胰岛素抵抗的其他特征，如微量白蛋白尿。MetS已成为一个影响全球20%-30%人口的主要公共卫生问题。本研究利用健康检查来调查代谢综合征是否与听力损失有关。
方法
对2010年1月至2020年12月期间共94223名接受包括听力测试在内的健康检查的人进行了评估。受试者被分为两组，有代谢综合征组和无代谢综合征组。此外，系统检索了Scopus、Embase、PubMed和Cochrane图书馆，使用“听力损失”和“代谢综合征”等关键词，查找评估两者关系的研究。
结果
在94223名受试者中，11414名（12.1%）患有代谢综合征，82809名没有。两组受试者平均年龄分别为46.1岁和43.9岁。对有和没有代谢综合征的受试者按年龄进行听力阈值比较，结果显示，在所有年龄组中，患有代谢综合征的受试者的平均纯音听力阈值显著高于没有代谢综合征的受试者（<0.001）。代谢综合征各组成部分数量为0、1、2、3、4和5的受试者的听力损失率分别为7.9%、12.1%、13.8%、13.8%、15.5%和16.3%，表明代谢综合征组成部分的数量与听力损失率之间存在显著关联（<0.0001）。代谢综合征有四个组成部分（腰围、血压、甘油三酯和空腹血糖浓度）的受试者听力损失的优势比显著更高（<0.0001）。
结论
代谢综合征的组成部分数量与感音神经性听力损失率呈正相关。
Zotero 插件