Guo Dongye, Zhang Andi, Zou Tianyuan, Ding Rui, Chen Kaili, Pan Yi, Ji Peilin, Ye Bin, Xiang Mingliang
Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Aging Neurosci. 2022 Jul 29;14:930105. doi: 10.3389/fnagi.2022.930105. eCollection 2022.
With the increase in life expectancy in the global population, aging societies have emerged in many countries, including China. As a common sensory defect in the elderly population, the prevalence of age-related hearing loss and its influence on society are increasing yearly. Metabolic syndrome is currently one of the main health problems in the world. Many studies have demonstrated that metabolic syndrome and its components are correlated with a variety of age-related diseases of the peripheral sensory system, including age-related hearing loss. Both age-related hearing loss and metabolic syndrome are high-prevalence chronic diseases, and many people suffer from both at the same time. In recent years, more and more studies have found that mitochondrial dysfunction occurs in both metabolic syndrome and age-related hearing loss. Therefore, to better understand the impact of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction, we reviewed the literature related to the relationship between age-related hearing loss and metabolic syndrome and their components to discern the possible role of mitochondria in both conditions.
随着全球人口预期寿命的增加，包括中国在内的许多国家都出现了老龄化社会。作为老年人群中常见的感觉缺陷，年龄相关性听力损失的患病率及其对社会的影响逐年增加。代谢综合征是目前世界上主要的健康问题之一。许多研究表明，代谢综合征及其组分与包括年龄相关性听力损失在内的多种外周感觉系统的年龄相关性疾病相关。年龄相关性听力损失和代谢综合征都是高患病率的慢性疾病，许多人同时患有这两种疾病。近年来，越来越多的研究发现代谢综合征和年龄相关性听力损失中均出现线粒体功能障碍。因此，为了从线粒体功能障碍的角度更好地理解代谢综合征对年龄相关性听力损失的影响，我们回顾了与年龄相关性听力损失和代谢综合征及其组分之间关系相关的文献，以辨别线粒体在这两种情况中可能发挥的作用。
