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腰椎退行性椎间盘疾病短节段腰椎手术后脊柱再次手术和关节置换手术的危险因素:一项基于人群的队列研究

Risk Factors for Spine Reoperation and Joint Replacement Surgeries after Short-Segment Lumbar Spinal Surgeries for Lumbar Degenerative Disc Disease: A Population-Based Cohort Study.

作者信息

Wu Meng-Huang, Wu Christopher, Lin Jiann-Her, Chen Li-Ying, Lee Ching-Yu, Huang Tsung-Jen, Hsieh Yi-Chen, Chien Li-Nien

机构信息

Department of Orthopedics, Taipei Medical University Hospital, Taipei 110301, Taiwan.

Department of Orthopaedics, School of Medicine, College of Medicine Taipei Medical University, Taipei 110301, Taiwan.

出版信息

J Clin Med. 2021 Oct 31;10(21):5138. doi: 10.3390/jcm10215138.

Abstract

BACKGROUND

Short-segment lumbar spinal surgery is the most performed procedure for treatment of degenerative disc disease. However, population-based data regarding reoperation and joint replacement surgeries after short-segment lumbar spinal surgery is limited.

METHODS

The study was a retrospective cohort design using the Taiwan National Health Insurance Research Database for data collection. Patients selected were diagnosed with lumbar degenerative disc disease and undergone lumbar discectomy surgery between 2002 and 2013. The Kaplan-Meier method was used to estimate the incidence of 1-year spine reoperation and joint replacement surgeries, and the Cox proportional hazard regression was used to examine risk factors associated with the outcomes of interest.

RESULTS

A total of 90,105 patients were included. Incidences of 1-year spine reoperation and joint replacement surgeries for the hip and knee were 0.27, 0.04, and 0.04 per 100 people/month. Compared to fusion with the fixation group, fusion without fixation and the non-fusion group had higher risks of spine reoperation. Risk factors associated with spine reoperation included fusion without fixation, non-fusion surgery, age ≥ 45 years old, male gender, diabetes, a Charlson Comorbidity Index = 0, lowest social economic status, and steroid use history. Spine surgeries were not risk factors for joint replacement surgeries.

CONCLUSIONS

Non-fusion surgery and spinal fusion without fixation had higher risks for spine reoperation. Spine surgeries did not increase the risk for joint replacement surgeries.

摘要

背景

短节段腰椎手术是治疗椎间盘退变疾病最常施行的手术。然而,关于短节段腰椎手术后再次手术及关节置换手术的基于人群的数据有限。

方法

本研究采用回顾性队列设计,利用台湾全民健康保险研究数据库收集数据。选取2002年至2013年间被诊断为腰椎间盘退变疾病并接受腰椎间盘切除术的患者。采用Kaplan-Meier方法估计1年脊柱再次手术及关节置换手术的发生率,并采用Cox比例风险回归分析与感兴趣结局相关的危险因素。

结果

共纳入90,105例患者。每100人/月的1年脊柱再次手术、髋关节和膝关节置换手术的发生率分别为0.27、0.04和0.04。与融合内固定组相比,非融合组和融合无固定组有更高的脊柱再次手术风险。与脊柱再次手术相关的危险因素包括融合无固定、非融合手术、年龄≥45岁、男性、糖尿病、Charlson合并症指数=0、社会经济地位最低以及有使用类固醇药物史。脊柱手术不是关节置换手术的危险因素。

结论

非融合手术和无固定的脊柱融合术有更高的脊柱再次手术风险。脊柱手术不会增加关节置换手术的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e0/8584353/904492f08596/jcm-10-05138-g001.jpg

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