Plinta Klaudia, Plewka Andrzej, Pawlicki Krzysztof, Zmarzły Nikola, Wójcik-Pędziwiatr Magdalena, Rudziński Marcin, Krzak-Kubica Agnieszka, Doręgowska-Stachera Magdalena, Rudzińska-Bar Monika
Neurology Department, Institute of Medical Science, University of Opole, 45-040 Opole, Poland.
Institute of Health Sciences, University of Opole, 45-040 Opole, Poland.
J Clin Med. 2021 Nov 5;10(21):5181. doi: 10.3390/jcm10215181.
Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington's disease (HD). Clinical pictures of HD can be very diverse, which makes it difficult to assess its severity; however, molecular markers may be helpful. The aim of the study was to determine the relationship between HD severity and the plasma BDNF concentration in HD patients. The study recruited 42 patients with diagnosed and genetically confirmed HD and 40 healthy volunteers. BDNF levels were determined in plasma with the enzyme-linked immunosorbent assay (ELISA). Correlations between BDNF levels and clinical profiles and HD severity were also investigated. The BDNF level was significantly lower in HD patients compared to the control. There was no correlation between the BDNF level and motor symptoms and cognitive impairment. In the early disease stages, BDNF levels were associated with a better neurological examination, independence, and functional evaluation, in contrast to later HD stages, where the correlations were inverse. Multidirectional correlations between parameters of saccadic disorders and the BDNF level do not allow for drawing a conclusion, whether or not there is a relationship between the severity of saccadic disorders and the BDNF concentration.
脑源性神经营养因子（BDNF）参与神经元的存活和成熟，还促进和控制神经发生。在包括亨廷顿舞蹈症（HD）在内的许多神经退行性疾病中，其水平会降低。HD的临床症状可能多种多样，这使得评估其严重程度变得困难；然而，分子标志物可能会有所帮助。该研究的目的是确定HD患者中HD严重程度与血浆BDNF浓度之间的关系。该研究招募了42名经诊断且基因确诊的HD患者和40名健康志愿者。采用酶联免疫吸附测定（ELISA）法测定血浆中的BDNF水平。还研究了BDNF水平与临床特征及HD严重程度之间的相关性。与对照组相比，HD患者的BDNF水平显著降低。BDNF水平与运动症状和认知障碍之间没有相关性。在疾病早期，BDNF水平与更好的神经学检查、独立性和功能评估相关，而在HD后期，相关性则相反。扫视障碍参数与BDNF水平之间的多向相关性无法得出扫视障碍严重程度与BDNF浓度之间是否存在关系的结论。
