School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia.
Mater Research, Translational Research Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
Int J Mol Sci. 2021 Oct 21;22(21):11366. doi: 10.3390/ijms222111366.
Tumors exist in a complex milieu where interaction with their associated microenvironment significantly contributes to disease progression. Cancer-associated fibroblasts (CAFs) are the primary component of the tumor microenvironment and participate in complex bidirectional communication with tumor cells. CAFs support the development of various hallmarks of cancer through diverse processes, including direct cell-cell contact, paracrine signaling, and remodeling and deposition of the extracellular matrix. Calcium signaling is a key second messenger in intra- and inter-cellular signaling pathways that contributes to cancer progression; however, the links between calcium signaling and CAFs are less well-explored. In this review, we put into context the role of calcium signaling in interactions between cancer cells and CAFs, with a focus on migration, proliferation, chemoresistance, and genetic instability.
肿瘤存在于复杂的环境中，其与相关微环境的相互作用显著促进了疾病的进展。癌相关成纤维细胞（CAFs）是肿瘤微环境的主要组成部分，并与肿瘤细胞进行复杂的双向通讯。CAFs 通过多种过程支持癌症的各种特征的发展，包括直接细胞-细胞接触、旁分泌信号传递以及细胞外基质的重塑和沉积。钙信号是细胞内和细胞间信号通路中的关键第二信使，有助于癌症的进展；然而，钙信号与 CAFs 之间的联系还不太清楚。在这篇综述中，我们将钙信号在癌细胞与 CAFs 相互作用中的作用置于上下文中，重点关注迁移、增殖、化疗耐药性和遗传不稳定性。
