比较纳米羟磷灰石移植体和其他骨移植材料修复牙周骨内缺损的疗效：系统评价和 Meta 分析。

Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis.

机构信息

Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan.

Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah 41311, Al Munawwarah, Saudi Arabia.

出版信息

Int J Mol Sci. 2021 Nov 6;22(21):12021. doi: 10.3390/ijms222112021.

OBJECTIVE

To compare the results of periodontal infrabony lesions treated using nanohydroxyapatite (NcHA) graft with other bone grafts (BGs).

METHODS

Four electronic databases were searched including PubMed (NLM), Embase (Ovid), Medline, and Dentistry and Oral Sciences (EBSCO). The inclusion criteria included randomised controlled clinical trials (RCTs) and controlled clinical trials (CCTs). The clinical results of NcHA were compared with other BGs. For clinical attachment level (CAL) gain, probing pocket depth (PPD) decrease, and gingival recession (REC) change, weighted averages and forest plots were computed.

RESULTS

Seven RCTs fulfilled the selection criteria that were included. When NcHA was compared to other BGs, no clinically significant differences were found in terms of each outcome assessed, except the REC change for synthetic BGs as compared to NcHA.

CONCLUSIONS

The use of an NcHA graft showed equivalent results compared to other types of BGs. To further validate these findings, future studies are required to compare the NcHA and various BGs over longer time periods and in furcation deficiencies.

目的

比较使用纳米羟基磷灰石（NcHA）移植物治疗牙周骨下缺损的效果与其他骨移植物（BGs）的效果。

方法

检索了四个电子数据库，包括 PubMed（NLM）、Embase（Ovid）、Medline 和 Dentistry and Oral Sciences（EBSCO）。纳入标准包括随机对照临床试验（RCTs）和对照临床试验（CCTs）。将 NcHA 的临床结果与其他 BGs 进行比较。对于临床附着水平（CAL）的增加、探诊袋深度（PPD）的减少和牙龈退缩（REC）的变化，计算了加权平均值和森林图。