Liang Yongxi, Luan Xianghong, Liu Xiaohua
Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Department of Periodontics, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Bioact Mater. 2020 Feb 28;5(2):297-308. doi: 10.1016/j.bioactmat.2020.02.012. eCollection 2020 Jun.
Periodontal disease (PD) is one of the most common inflammatory oral diseases, affecting approximately 47% of adults aged 30 years or older in the United States. If not treated properly, PD leads to degradation of periodontal tissues, causing tooth movement, and eventually tooth loss. Conventional clinical therapy for PD aims at eliminating infectious sources, and reducing inflammation to arrest disease progression, which cannot achieve the regeneration of lost periodontal tissues. Over the past two decades, various regenerative periodontal therapies, such as guided tissue regeneration (GTR), enamel matrix derivative, bone grafts, growth factor delivery, and the combination of cells and growth factors with matrix-based scaffolds have been developed to target the restoration of lost tooth-supporting tissues, including periodontal ligament, alveolar bone, and cementum. This review discusses recent progresses of periodontal regeneration using tissue-engineering and regenerative medicine approaches. Specifically, we focus on the advances of biomaterials and controlled drug delivery for periodontal regeneration in recent years. Special attention is given to the development of advanced bio-inspired scaffolding biomaterials and temporospatial control of multi-drug delivery for the regeneration of cementum-periodontal ligament-alveolar bone complex. Challenges and future perspectives are presented to provide inspiration for the design and development of innovative biomaterials and delivery system for new regenerative periodontal therapy.
牙周病（PD）是最常见的炎性口腔疾病之一，在美国约47%的30岁及以上成年人受其影响。如果治疗不当，牙周病会导致牙周组织退化，引起牙齿移动，并最终导致牙齿脱落。牙周病的传统临床治疗旨在消除感染源，并减轻炎症以阻止疾病进展，但无法实现已丧失的牙周组织的再生。在过去二十年中，已开发出各种牙周再生疗法，如引导组织再生（GTR）、釉基质衍生物、骨移植、生长因子递送，以及细胞和生长因子与基于基质的支架的组合，以针对包括牙周膜、牙槽骨和牙骨质在内的已丧失的牙齿支持组织的修复。本综述讨论了使用组织工程和再生医学方法进行牙周再生的最新进展。具体而言，我们关注近年来用于牙周再生的生物材料和可控药物递送的进展。特别关注先进的仿生支架生物材料的开发以及用于牙骨质 - 牙周膜 - 牙槽骨复合体再生的多药物递送的时空控制。还提出了挑战和未来展望，为新型牙周再生疗法的创新生物材料和递送系统的设计与开发提供灵感。
