Beitz J, Schneider S, Riedel A, Mest H J
Prostaglandins Leukot Med. 1987 Jul;28(2):215-20. doi: 10.1016/0262-1746(87)90165-x.
The present study suggests that a diminished level of HDL is connected with an enhanced susceptibility to arrhythmogenic stimuli only in rats pretreated with a diet deficient in polyunsaturated fatty acids (PUFA), but not after a PUFA-rich or pellet diet. The endogenous level of total cholesterol did not influence the thresholds for ventricular flutter or ventricular fibrillation in aconitine-induced arrhythmia in rats or in ouabain-induced arrhythmia in guinea pigs.
本研究表明，仅在食用多不饱和脂肪酸（PUFA）缺乏饮食预处理的大鼠中，高密度脂蛋白（HDL）水平降低与致心律失常刺激的易感性增强有关，而在富含PUFA的饮食或颗粒饲料喂养后则不然。总胆固醇的内源性水平并不影响大鼠乌头碱诱导的心律失常或豚鼠哇巴因诱导的心律失常中室性扑动或室性颤动的阈值。
