意大利多重化学敏感性（MCS）临床与治疗管理专家共识

Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).

作者信息

Damiani Giovanni, Alessandrini Marco, Caccamo Daniela, Cormano Andrea, Guzzi Gianpaolo, Mazzatenta Andrea, Micarelli Alessandro, Migliore Alberto, Piroli Alba, Bianca Margherita, Tapparo Ottaviano, Pigatto Paolo Daniele Maria

机构信息

Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.

出版信息

Int J Environ Res Public Health. 2021 Oct 27;18(21):11294. doi: 10.3390/ijerph182111294.

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

多重化学物质敏感症（MCS）是一种多系统、复发性的环境紊乱疾病，在一般人群中，针对不同暴露物质（如农药、溶剂、有毒金属和霉菌），当暴露量低于根据年龄和性别计算的阈限值（TLV）时，就会发作。MCS是一种以皮肤、过敏、胃肠道、风湿病学、内分泌学、心脏病学和神经学的体征和症状为特征的综合征。我们对文献进行了系统综述，以总结当前的临床和治疗证据，然后开展了一项电子德尔菲共识研究。确定了四个主要研究领域（诊断、治疗、住院和急诊），并由10名专家和一名MCS患者进行了讨论。因此，首个意大利MCS共识有双重目标：（a）通过规范对MCS患者的临床和治疗管理，提高医护人员和患者对MCS的认识；（b）改善并阐明循证医学（EBM）不支持的MCS误解。