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[内源性精神病患者中HLA抗原的分布特征]

[Features of the distribution of HLA-antigens among patients with endogenous psychoses].

作者信息

Sorokina T T, Evsegneev R A, Levin V I, Semenov G V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(6):885-8.

PMID:3477049
Abstract

Distribution of HLA antigens of A and B loci was studied in 200 schizophrenics, 77 patients with manic-depressive psychosis of different forms, and in 350 healthy individuals. The findings included a significant elevation in the levels of the B7 antigen in both groups of patients, of antigen B12 in individuals with paroxysmal schizophrenia as well as a decrease in the concentrations of antigen B35 in recurrent schizophrenia. Patients with monopolar manic-depressive psychosis showed increased content of antigen B14 and decreased levels of antigen B5. The data obtained confirm heterogeneity of endogenic psychoses with regard to this sign.

摘要

对200名精神分裂症患者、77名不同类型躁狂抑郁症患者以及350名健康个体进行了HLA A和B位点抗原分布的研究。研究结果包括:两组患者的B7抗原水平均显著升高,阵发性精神分裂症患者的B12抗原水平升高,而复发型精神分裂症患者的B35抗原浓度降低。单相躁狂抑郁症患者的B14抗原含量增加,B5抗原水平降低。所获数据证实了内源性精神病在该指标方面的异质性。

相似文献

1
[Features of the distribution of HLA-antigens among patients with endogenous psychoses].[内源性精神病患者中HLA抗原的分布特征]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(6):885-8.
2
[Evaluation of the HLA system in a sample of patients with endogenous depression].[内源性抑郁症患者样本中HLA系统的评估]
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1981 Sep-Oct;9(5):363-6.
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Human leukocyte antigen system not closely linked to or associated with bipolar manic-depressive illness.人类白细胞抗原系统与双相躁狂抑郁症没有紧密联系或关联。
Biol Psychiatry. 1979 Aug;14(4):615-36.
4
[HLA antigens and schizophrenia].
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(7):1016-8.
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[Late endogenous psychoses in light of clinico-genealogic research].[基于临床谱系研究的迟发性内源性精神病]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(9):1367-71.
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[Modifications of lymphocyte HL-A antigens as a consequence of therapy in patients with manic-depressive psychosis].[躁狂抑郁症患者治疗后淋巴细胞HL - A抗原的改变]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(4):509-17.
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[Association between the tryptophan hydroxylase (TPH) gene polymorphic markers and endogenous psychoses].
Genetika. 2009 Dec;45(12):1668-73.
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Serum immunoglobulin levels in schizoaffective disorders (manic and depressive).
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HLA antigens in affective disorders and schizophrenia.情感障碍和精神分裂症中的人类白细胞抗原(HLA)抗原
J Affect Disord. 1981 Mar;3(1):17-24. doi: 10.1016/0165-0327(81)90015-x.
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HLA antigens in schizophrenia, major depressive disorder, and schizoaffective disorder.精神分裂症、重度抑郁症和分裂情感性障碍中的人类白细胞抗原(HLA)抗原
Med Microbiol Immunol. 1983;172(1):57-65. doi: 10.1007/BF02123678.

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