HLA antigens in schizophrenia, major depressive disorder, and schizoaffective disorder.

We carried out a study with 150 patients suffering from endogenous psychosis in order to confirm earlier findings of an association between HLA and various psychiatric syndromes. Our sample consisted of 107 schizophrenics, 25 patients with recurrent endogenous major depressive disorder, and 18 schizoaffectives. A significant excess of HLA B27 was found among schizophrenics with a family history of endogenous psychosis. This association is consistent with reported earlier studies. The preliminary data on the schizoaffective sample suggest a positive association with HLA B7. The data on patients with endogenous major depressive disorder failed to identify an association with HLA.