Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Jianxi Nafutang Pharmaceutical Co., Ltd., Zhangshu 331200, China.
Molecules. 2021 Oct 25;26(21):6437. doi: 10.3390/molecules26216437.
A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.
建立了一种新颖的酰胺辅助重排反应，用于高效合成 1,3-二苯基脲衍生物。通过该方法可以获得各种电子和空间位阻不同的 1,3-二苯基脲衍生物，产率良好至优秀，并提出了反应机理。
