评价百里醌对不同口腔致病菌的抗菌效果：一项体外研究。
Evaluation of the Antimicrobial Effect of Thymoquinone against Different Dental Pathogens: An In Vitro Study.
机构信息
Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
出版信息
Molecules. 2021 Oct 26;26(21):6451. doi: 10.3390/molecules26216451.
This study aimed to evaluate the antimicrobial effect of Thymoquinone (TQ) on four different oral microorganisms. Minimum Bactericidal Concentration (MBC), Minimum Inhibition Concentration (MIC), Broth microdilution, and Well diffusion tests were used to determine the optimum antimicrobial concentrations of TQ against and over 1, 3, 6, 12 and 24 h. Chlorhexidine 0.12% was selected as a positive control. The inhibitory effect of TQ on bacterial growth was most noticeable with while the least affected was TQ's MBC and MIC for and were comparable 2 mg/mL and 3 mg/mL, respectively. was most resistant to TQ and displayed a value of 5 mg/mL and 4 mg/mL for MIC and MBC, respectively. The viable count of different strains after exposure to TQ's MBC values was most noticeable with followed by and while was least affected. This study emphasized the promising antimicrobial effect of TQ against the four main oral microorganisms. It has a potential preventive effect against dental caries as well as other oral diseases.
本研究旨在评估百里醌（TQ）对四种不同口腔微生物的抗菌效果。采用最低杀菌浓度（MBC）、最低抑菌浓度（MIC）、肉汤微量稀释法和孔扩散法，在 1、3、6、12 和 24 小时内确定 TQ 对 和 的最佳抗菌浓度。选择 0.12%洗必泰作为阳性对照。TQ 对细菌生长的抑制作用最明显的是 ，而受影响最小的是 TQ 的 MBC 和 MIC 对于 和 分别为 2 mg/mL 和 3 mg/mL。 对 TQ 的抵抗力最强，MIC 和 MBC 值分别为 5 mg/mL 和 4 mg/mL。暴露于 TQ 的 MBC 值后，不同菌株的活菌计数以 最为明显，其次是 和 ，而 受影响最小。本研究强调了 TQ 对四种主要口腔微生物具有有前景的抗菌作用。它可能对预防龋齿和其他口腔疾病有预防作用。
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