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植物化学分析与黑孜然（ Linn.）种子抗龋齿生物膜潜能。

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds ( Linn.).

机构信息

Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang, Indonesia.

Department of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Jawa Barat, Indonesia.

出版信息

Drug Des Devel Ther. 2024 May 29;18:1917-1932. doi: 10.2147/DDDT.S454217. eCollection 2024.

DOI:10.2147/DDDT.S454217
PMID:38828022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144408/
Abstract

The oral cavity is an excellent place for various microorganisms to grow. and are Gram-negative bacteria found in the oral cavity as pioneer biofilm formers on the tooth surface that cause caries. Caries treatment has been done with antibiotics and therapeutics, but the resistance level of and bacteria necessitates the exploration of new drug compounds. Black cumin ( Linn.) is known to contain secondary metabolites that have antioxidant, antibacterial, anti-biofilm, anti-inflammatory and antifungal activities. The purpose of this review article is to present data on the potential of Linn seeds as anti-biofilm. This article will discuss biofilm-forming bacteria, the resistance mechanism of antibiotics, the bioactivity of extracts and seed isolates together with the Structure Activity Relationship (SAR) review of compound isolates. We collected data from reliable references that will illustrate the potential of seeds as anti-biofilm drug.

摘要

口腔是各种微生物生长的绝佳场所。和是口腔中发现的革兰氏阴性菌，作为牙面先驱生物膜形成者，导致龋齿。龋齿的治疗已经使用了抗生素和治疗药物，但和细菌的耐药水平需要探索新的药物化合物。黑孜然（ Linn.）已知含有具有抗氧化、抗菌、抗生物膜、抗炎和抗真菌活性的次生代谢物。本文的目的是介绍关于黑孜然种子作为抗生物膜的潜在数据。本文将讨论生物膜形成细菌、抗生素的耐药机制、提取物和种子分离物的生物活性以及化合物分离物的构效关系（SAR）综述。我们从可靠的参考文献中收集数据，这些数据将说明黑孜然种子作为抗生物膜药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/be4320419c88/DDDT-18-1917-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/add2e08725a4/DDDT-18-1917-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/dc12b0c42b28/DDDT-18-1917-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/5308c73face9/DDDT-18-1917-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/16944098e990/DDDT-18-1917-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/1dc8552ebec7/DDDT-18-1917-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/af15a9eda83d/DDDT-18-1917-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/f507a8336d81/DDDT-18-1917-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/d178f6c4ce2a/DDDT-18-1917-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/be4320419c88/DDDT-18-1917-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/add2e08725a4/DDDT-18-1917-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/7c8d1be2712e/DDDT-18-1917-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/dc12b0c42b28/DDDT-18-1917-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/5308c73face9/DDDT-18-1917-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/16944098e990/DDDT-18-1917-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/1dc8552ebec7/DDDT-18-1917-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/af15a9eda83d/DDDT-18-1917-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/f507a8336d81/DDDT-18-1917-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/d178f6c4ce2a/DDDT-18-1917-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc63/11144408/be4320419c88/DDDT-18-1917-g0010.jpg

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AMB Express. 2022 Dec 12;12(1):154. doi: 10.1186/s13568-022-01499-3.
3
Antimicrobial activities and mechanisms of extract and components of herbs in East Asia.
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4
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Pathogens. 2022 Sep 28;11(10):1114. doi: 10.3390/pathogens11101114.
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Biological Potential of the Main Component, Thymoquinone, of in Pulp Therapy-In Vitro Study.百里醌的主要成分在牙髓治疗中的生物学潜力——体外研究
Life (Basel). 2022 Sep 15;12(9):1434. doi: 10.3390/life12091434.
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8
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9
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