The oral cavity is an excellent place for various microorganisms to grow. and are Gram-negative bacteria found in the oral cavity as pioneer biofilm formers on the tooth surface that cause caries. Caries treatment has been done with antibiotics and therapeutics, but the resistance level of and bacteria necessitates the exploration of new drug compounds. Black cumin ( Linn.) is known to contain secondary metabolites that have antioxidant, antibacterial, anti-biofilm, anti-inflammatory and antifungal activities. The purpose of this review article is to present data on the potential of Linn seeds as anti-biofilm. This article will discuss biofilm-forming bacteria, the resistance mechanism of antibiotics, the bioactivity of extracts and seed isolates together with the Structure Activity Relationship (SAR) review of compound isolates. We collected data from reliable references that will illustrate the potential of seeds as anti-biofilm drug.