luteapyrone，一种从丝状真菌中分离得到的新型 ƴ-吡喃酮。

Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus .

机构信息

Unit of Food Microbiology, Department for Farm Animals and Veterinary Public Health, Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria.

出版信息

Molecules. 2021 Oct 30;26(21):6589. doi: 10.3390/molecules26216589.

DOI:10.3390/molecules26216589

PMID:34770997

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8588484/

Abstract

In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).

摘要

在筛选新的生物活性微生物代谢产物的过程中，我们在一种最近描述的微生物丝状真菌 BiMM-F96/DF4 中发现了一种新型的γ-吡喃酮衍生物，我们提议将其命名为 luteapyrone。该化合物是通过快速色谱法和制备高效液相色谱法从真菌在改良酵母提取物蔗糖培养基上培养的培养提取物中分离得到的。通过 NMR 和 LC-MS 确定了化学结构。新化合物对三种哺乳动物细胞系（HEK 263、KB-3.1 和 Caco-2）没有细胞毒性。同样，在所测试的微生物（革兰氏阳性和阴性细菌、酵母和真菌）中也没有观察到抗菌活性。