Department of Pharmacy, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China.
Central Laboratory, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China.
Molecules. 2021 Oct 31;26(21):6598. doi: 10.3390/molecules26216598.
There are abundant natural diterpenoids in the plants of the genus from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus , which could be further classified into three main types according to the substitution pattern of ring A and oxygen-containing functions at ring B. A variety of studies have demonstrated that these compounds exert a wide range of bioactivities both in vitro and in vivo including anticancer, anti-inflammatory, anti-HIV, antifertility, neurotrophic, and cholesterol-lowering effects, which is reviewed herein. Meanwhile, the fascinating structure-activity relationship is also concluded in this review in the hope of providing an easy access to available information for the synthesis and optimization of efficient drugs.
瑞香科结香属植物中含有丰富的二萜类化合物，具有 5/7/6-三环骨架系统，通常具有邻酯基。迄今为止，已从结香属的种中分离出 135 种二萜类化合物，根据 A 环取代模式和 B 环含氧官能团的不同，可进一步分为 3 种主要类型。大量研究表明，这些化合物在体外和体内均具有广泛的生物活性，包括抗癌、抗炎、抗 HIV、抗生育、神经营养和降胆固醇作用，本文对此进行了综述。同时，本文还总结了有趣的结构-活性关系，希望为高效药物的合成和优化提供易于获取的信息。
