从. 中分离得到瑞香烷二萜类化合物，并对其结构进行了鉴定，同时研究了其抗 HIV 活性。
Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from .
机构信息
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
出版信息
J Nat Prod. 2020 Nov 25;83(11):3270-3277. doi: 10.1021/acs.jnatprod.0c00540. Epub 2020 Sep 30.
Abstract
Five new [daphneodorins D-H (, , and -)] and seven known daphnane diterpenoids (- and -) were isolated from . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (-) showed potent anti-HIV activity with EC values of 1.5-7.7 nM.
摘要
从瑞香科植物中分离得到了 5 个新的[瑞香毒素 D-H（，，和-）]和 7 个已知的瑞香烷二萜（-和-）。通过广泛的物理化学和光谱分析阐明了新化合物的结构。对分离得到的化合物进行了抗 HIV 活性评价，以检测它们对 MT4 细胞中 HIV-1 感染的抑制作用。9 个瑞香烷二萜原酸酯（-）具有较强的抗 HIV 活性，EC 值为 1.5-7.7 nM。
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