Zastavnyĭ I V, Shablovskaia E A, Loziuk L V, Volos O P, Shloma B V
Vopr Virusol. 1978 Jan-Feb(1):79-81.
The results of the study of rimantadine effectiveness in a viral-bacterial infection in white mice caused by a mixture of influenza A2 virus (10 LD50) and hemolytic streptococcus group A (350 million bacteria). The drug showed no prophylactic or therapeutic effect in the mixed infection, whereas in influenza infection in the animals which served as a positive control rimantadine had marked antiviral activity (P less than 0.001). It is assumed that the lack of the drug effectiveness against the mixed infection is due to the formation in the animals of virus-microbe complexes which are conducive to an increase of infectious virus titers and virus resistance to various treatments.
关于金刚烷胺对由甲型流感病毒（10个半数致死量）和A组溶血性链球菌（3.5亿个细菌）混合物引起的小白鼠病毒 - 细菌感染的疗效研究结果。该药物在混合感染中未显示出预防或治疗效果，而在作为阳性对照的动物流感感染中，金刚烷胺具有显著的抗病毒活性（P小于0.001）。据推测，该药物对混合感染缺乏疗效是由于动物体内形成了病毒 - 微生物复合物，这有利于感染性病毒滴度的增加以及病毒对各种治疗的抗性增强。
