Krylov V F, Ketiladze E S, Smagulova E G, Alekseeva A A, Nefelova M M
Vopr Virusol. 1978 May-Jun(3):277-82.
The therapeutic and prophylactic efficacy of rimantadine in familial foci during influenza A1 outbreaks was studied. The observations included 28 experimental foci and 26 control (altogether 146 subjects varying in ages from 4 to 71 years). The foci were selected at random (the alphabet principle). In the experimental foci the patients were treated with rimantadine given in single doses of 300 mg on the first day, 200 mg on the second, and 100 mg each on the 3rd and 4th days. The contacts were also given rimantadine, 100 mg each for 7 to 10 days. In the control foci the patients received symptomatic drugs and contacts were only observed by physicians. Rimantadine was shown to be effective therapeutically if the treatment was started on the first day of the disease. As compared with the control group, in the treated patients the temperature became normal and the main symptoms of the disease regressed within shorter periods of time. The prophylactic effect was also positive: in experimental foci repeated diseases occurred only in 3 subjects (6%) and in controls 13 subjects (30%). The prophylactic effectiveness of the drug is also indicated by a decline in the number of inapparent forms: in experimental foci 26%, in control 56%. The drug may be recommended for treatment and prevention of influenza in familial foci when the disease is caused by A1 virus.
研究了金刚乙胺在甲型流感A1暴发期间家庭疫源地中的治疗和预防效果。观察对象包括28个试验疫源地和26个对照疫源地（共146名年龄在4岁至71岁之间的受试者）。疫源地是随机选择的（按字母顺序原则）。在试验疫源地，患者接受金刚乙胺治疗，第一天单次服用300毫克，第二天服用200毫克，第三天和第四天各服用100毫克。密切接触者也服用金刚乙胺，每人100毫克，持续7至10天。在对照疫源地，患者接受对症药物治疗，密切接触者仅由医生观察。结果表明，如果在疾病第一天开始治疗，金刚乙胺具有治疗效果。与对照组相比，接受治疗的患者体温恢复正常，疾病的主要症状在更短时间内消退。预防效果也很显著：在试验疫源地，仅3名受试者（6%）再次发病，而在对照疫源地有13名受试者（30%）再次发病。不显性感染形式的数量减少也表明了该药物的预防效果：在试验疫源地为26%，在对照疫源地为56%。当疾病由A1病毒引起时，该药物可推荐用于家庭疫源地流感的治疗和预防。
