Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; NeuroTech Center, University of Pittsburgh Brain Institute, Pittsburgh, PA, USA.
Curr Opin Biotechnol. 2021 Dec;72:112-120. doi: 10.1016/j.copbio.2021.10.008. Epub 2021 Nov 10.
Recent neuroscience studies have highlighted the critical role of glial cells in information processing. This has increased the demand for technologies that selectively modulate glial cells that regulate the excitation-inhibition balance of neural network function. Engineered technologies that modulate glial activity may be necessary for precise tuning of neural network activity in higher-order brain function. This perspective summarizes how glial cells regulate excitation and inhibition of neural circuits, highlights available technologies for glial modulation, and discusses current challenges and potential opportunities for glial engineering technologies.
最近的神经科学研究强调了神经胶质细胞在信息处理中的关键作用。这增加了对技术的需求，这些技术可以选择性地调节神经胶质细胞，调节神经网络功能的兴奋-抑制平衡。调节神经胶质细胞活性的工程技术可能是精确调整高级脑功能中神经网络活动所必需的。本文概述了神经胶质细胞如何调节神经回路的兴奋和抑制，强调了现有的神经胶质调节技术，并讨论了神经胶质工程技术的当前挑战和潜在机遇。
