Kumar S, Khanna S S
Z Mikrosk Anat Forsch. 1977;91(1):131-43.
Uromastix hardwicki was found more resistant to insulin as compared to other poikilotherms and this insulin resistance appears to be related to the preponderance of glucagon secreting alpha-cells in this species. The magnitude and the persistence of hypolgycemia caused by insulin are directly dependent upon the quantity of the dose. The higher doses (2000 and 3000 U/kg) resulted into shocks, but the lack of correlation between hypoglycemia and shocks has been attributed to the direct effect of insulin on the nervous system. Histologically, insulin induced degranulation of both the beta- and alpha-cells. The physiological action of insulin is apparently greater at higher ambient temperature. The ability of insulin to damage beta- and alpha-cells in Uromastix hardwicki further gathers evidence for the similarity of these cell types with those of mammals and other vertebrates in being the source of insulin and glucagon respectively, and in controlling the blood glucose homeostasis in this lizard.
与其他变温动物相比，硬尾沙蜥对胰岛素更具抗性，这种胰岛素抗性似乎与该物种中分泌胰高血糖素的α细胞占优势有关。胰岛素引起的低血糖的程度和持续时间直接取决于剂量。较高剂量（2000和3000 U/kg）会导致休克，但低血糖与休克之间缺乏相关性归因于胰岛素对神经系统的直接作用。组织学上，胰岛素诱导β细胞和α细胞脱粒。胰岛素的生理作用在较高环境温度下显然更大。胰岛素损伤硬尾沙蜥β细胞和α细胞的能力进一步证明了这些细胞类型与哺乳动物和其他脊椎动物的细胞类型具有相似性，分别作为胰岛素和胰高血糖素的来源，并控制这种蜥蜴的血糖稳态。
