Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, T-1218 MCN, Nashville, TN 37232-2650, USA.
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21287, USA.
Clin Chest Med. 2021 Dec;42(4):767-776. doi: 10.1016/j.ccm.2021.08.011.
This article details the pros, cons, challenges/pitfalls, and elements required for the successful conduct of multicenter randomized trials, with specific focus on trials related to pleural diseases. Several networks dedicated to the multicenter study of important pleural conditions have developed, yielding practice-changing studies in pleural disease. This review describes the importance of multicenter trials, major elements required for the conduct of such trials, and lessons learned from the ongoing development of the Interventional Pulmonary Outcomes Group, a consortium of interventional pulmonologists dedicated to advancing diagnostic and management strategies in pleural, pulmonary parenchymal, and airway disease by generating high-quality multicenter evidence.
本文详细介绍了成功进行多中心随机试验的优缺点、挑战/陷阱以及所需的要素，特别关注与胸膜疾病相关的试验。已经有几个专门致力于重要胸膜疾病多中心研究的网络，这些网络已经开展了改变胸膜疾病实践的研究。本文综述了多中心试验的重要性、进行此类试验所需的主要要素，以及从正在发展的介入性肺病结果组（Interventional Pulmonary Outcomes Group）中吸取的经验教训。该联合会是一个介入性肺病学家的联盟，致力于通过生成高质量的多中心证据来推进胸膜、肺实质和气道疾病的诊断和管理策略。
