Kim Stephanie J, Shoback Dolores M
Division of Endocrinology and Metabolism, University of California, 400 Parnassus Avenue A549, San Francisco, CA 94143, USA.
Endocrine Research Unit - 111N, San Francisco Department of Veterans Affairs Medical Center, Division of Endocrinology and Metabolism, San Francisco VA Medical Center, University of California, 1700 Owens Street, 3rd floor Room 369, San Francisco, CA 94158, USA.
Endocrinol Metab Clin North Am. 2021 Dec;50(4):609-628. doi: 10.1016/j.ecl.2021.07.006.
Sporadic primary hyperparathyroidism is a common endocrinopathy, particularly afflicting postmenopausal women and both African American men and women. Although classic signs and symptoms of the disease are well appreciated and described, because of the ease and availability and low threshold for screening, the disorder often is diagnosed in patients who are minimally symptomatic or asymptomatic. Surgery conducted by experienced endocrine surgeons has a high cure rate, particularly if guided by concordant imaging. In patients who cannot safely undergo surgery or who fail to be cured, medical therapy with the oral calcimimetic cinacalcet is a validated option for controlling serum calcium levels.
散发性原发性甲状旁腺功能亢进是一种常见的内分泌疾病，尤其好发于绝经后女性以及非裔美国男性和女性。尽管该疾病的典型体征和症状已广为人知并得到描述，但由于筛查操作简便、可及性高且阈值低，该疾病常在症状轻微或无症状的患者中被诊断出来。由经验丰富的内分泌外科医生进行手术，治愈率很高，特别是在影像学检查的协同引导下。对于无法安全接受手术或手术未能治愈的患者，口服拟钙剂西那卡塞进行药物治疗是控制血清钙水平的有效选择。
