单细胞转录组学揭示了动基体目生物中的隐藏信息。

Single-cell transcriptomics reveals hidden information in trypanosomatids.

机构信息

DNA Replication and Repair Laboratory, Department of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.

Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil; The Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK.

出版信息

Trends Parasitol. 2022 Jan;38(1):4-6. doi: 10.1016/j.pt.2021.10.006. Epub 2021 Nov 10.

DOI:10.1016/j.pt.2021.10.006

PMID:34774423

Abstract

Dixenic parasites often encounter environmental extremes during the transition from vector to host. Preadapted transmission stages overcome these challenges to promote parasites' survival and ensure life cycle progression. Recently, Vigneron et al. and Briggs et al. used single-cell transcriptomics to investigate developmental stage specific gene expression patterns during parasite differentiation.

摘要

寄生原虫在从媒介到宿主的转变过程中常常会遇到环境极端情况。预先适应的传播阶段克服了这些挑战，促进了寄生虫的生存，并确保了生命周期的进展。最近，Vigneron 等人和 Briggs 等人使用单细胞转录组学技术研究了寄生虫分化过程中特定发育阶段的基因表达模式。