负载根皮素的多孔淀粉（Ph-PS）的制备、表征、体外释放及在体内斑马鱼模型中抗氧化应激的保护作用。
Phloretin loaded porous starch (Ph-PS): Preparation, characterization, in vitro release and protective effect against oxidative stress in vivo zebrafish model.
机构信息
School of Life Sciences, Nantong University, Nantong 226019, Jiangsu, China.
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China; Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
出版信息
Int J Biol Macromol. 2021 Dec 15;193(Pt B):2047-2053. doi: 10.1016/j.ijbiomac.2021.11.036. Epub 2021 Nov 10.
Phloretin loaded porous starch (Ph-PS) were prepared for its application in food. The effects of Ph-PS in vitro release and its ability against AAPH-induced oxidative stress in vivo zebrafish model were investigated. Ph-PS was prepared by absorption method, the physical and chemical characterization showed that PS decreased the crystallinity of Ph obviously. Ph-PS exhibited higher release amount and faster release rate of Ph compared to free Ph in vitro release study. What's more, the effect of Ph-PS reduced ROS generation and lipid peroxidation was better than that of free Ph in zebrafish model. These findings suggest Ph-PS is a new and simple strategy to improve dissolution rate and antioxidant ability of Ph.
负载根皮素多孔淀粉（Ph-PS）被制备用于食品应用。研究了 Ph-PS 在体外释放的影响及其在体内斑马鱼模型中对抗 AAPH 诱导的氧化应激的能力。Ph-PS 通过吸附法制备，物理化学特性表明 PS 明显降低了 Ph 的结晶度。与游离 Ph 相比，体外释放研究表明 Ph-PS 表现出更高的 Ph 释放量和更快的释放速度。此外，Ph-PS 降低 ROS 生成和脂质过氧化的效果优于游离 Ph。这些发现表明 Ph-PS 是一种提高 Ph 的溶解速率和抗氧化能力的新策略。
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