Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.
Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC.
J Am Acad Dermatol. 2022 Sep;87(3):541-550. doi: 10.1016/j.jaad.2021.10.058. Epub 2021 Nov 10.
Atopic dermatitis (AD) is a chronic, inflammatory skin disease associated with heterogeneous morphology, distribution, symptoms, severity, extent, longitudinal courses, quality of life burden, comorbidities, and treatment responses. This heterogeneity contributes to challenges in diagnosis, the characterization of disease activity, and therapeutic stratification.
To develop a framework to standardize AD assessment.
We propose a novel framework to assess AD based on a literature review and clinical experience.
DESCRIBE-AD is a framework that can effectively capture the clinical domains contributing to AD heterogeneity and includes both patient- and clinician-reported perspectives. DESCRIBE-AD includes assessments of Dermatitis morphology and phenotype, Evolution of disease, Symptom severity, Comorbid health disorders, Response to therapy, Intensity of lesions, Burden of disease, and Extent of lesions. Rather than placing the focus on any single, specific aspect of AD, DESCRIBE-AD allows for a comprehensive approach to the assessment and clinical management of AD.
DESCRIBE-AD is a novel framework that can be used to better describe the heterogeneity of AD and guide treatment decisions.
特应性皮炎（AD）是一种慢性炎症性皮肤病，具有异质性的形态、分布、症状、严重程度、范围、纵向病程、生活质量负担、合并症和治疗反应。这种异质性导致诊断、疾病活动特征和治疗分层方面的挑战。
制定一个标准化 AD 评估的框架。
我们提出了一种新的基于文献回顾和临床经验的 AD 评估框架。
DESCRIBE-AD 是一个能够有效捕捉导致 AD 异质性的临床领域的框架，包括患者和临床医生报告的观点。DESCRIBE-AD 包括对皮炎形态和表型、疾病演变、症状严重程度、合并健康障碍、治疗反应、病变强度、疾病负担和病变范围的评估。DESCRIBE-AD 不侧重于 AD 的任何单一特定方面，而是允许对 AD 的评估和临床管理采取全面的方法。
DESCRIBE-AD 是一个新的框架，可以更好地描述 AD 的异质性，并指导治疗决策。
