Internal Medicine, Faculty of Medicine & Health Sciences, United Arab Emirates University, United Arab Emirates.
Department of Chemistry, College of Science, United Arab Emirates (UAE) University, Al Ain, United Arab Emirates.
J Steroid Biochem Mol Biol. 2022 Jan;215:106023. doi: 10.1016/j.jsbmb.2021.106023. Epub 2021 Nov 10.
Although both vitamin D deficiency and obesity are highly prevalent in the UAE, the role of vitamin D metabolites in mediating obesity-related adverse health effects is not clear. We aimed to assess the role of vitamin D metabolites as potential mediators in the association between obesity, inflammation and metabolic risk factors.
277 participants who were part of a randomized controlled trial had their assessment that included clinical, anthropometric and physical activity data at baseline and at 6 months. Blood and urine samples were taken for measurements of serum 25(OH)D, 25(OH)D metabolites including 25(OH)D3), 25(OH)D2), 1,25(OH)2D3, 3-Epi-D3), metabolic and inflammatory markers and related biochemical variables. Multiple regression analysis used to assess the role of 25(OH)D metabolites in mediating the effect of increasing body mass index (BMI) on inflammation and metabolic risk factors.
Overall, 277 participants with complete 6 months follow up with a mean (±SD) age of 41 ± 12 and 204 (74%) female were included in the study. Blood pressure, inflammatory, metabolic and lipid profile markers significantly increased in overweight and obese subjects compared to subjects with normal BMI both at baseline and at 6 months (p < 0.05). 25(OH)D revealed significant association with age, gender, HbA1c and type 2 diabetes (p < 0.05). No statistically significant changes in any of 25(OH)D metabolites assessed. Multivariate analysis revealed significant and independent associations between BMI and important inflammatory and metabolic risk factors (p < 0.05). No similar association observed with 25(OH)D metabolites.
Although we found significant association between 25(OH)D and prevalence of type 2 diabetes, we found no evidence however to support a role of 25(OH)D metabolites in mediating the effect of BMI on inflammatory or metabolic risk factors.
尽管维生素 D 缺乏症和肥胖症在阿联酋都非常普遍，但维生素 D 代谢物在介导肥胖相关不良健康影响方面的作用尚不清楚。我们旨在评估维生素 D 代谢物作为肥胖、炎症和代谢危险因素之间关联的潜在介质的作用。
277 名参加随机对照试验的参与者进行了评估，包括基线和 6 个月时的临床、人体测量和身体活动数据。采集血液和尿液样本，以测量血清 25(OH)D、25(OH)D 代谢物（包括 25(OH)D3)、25(OH)D2)、1,25(OH)2D3、3-Epi-D3)、代谢和炎症标志物及相关生化变量。多元回归分析用于评估 25(OH)D 代谢物在介导体重指数 (BMI) 增加对炎症和代谢危险因素的影响中的作用。
总体而言，共有 277 名完成 6 个月随访的参与者纳入研究，平均（±SD）年龄为 41±12 岁，204 名（74%）为女性。与 BMI 正常的受试者相比，超重和肥胖受试者的血压、炎症、代谢和血脂谱标志物在基线和 6 个月时均显著升高（p<0.05）。25(OH)D 与年龄、性别、HbA1c 和 2 型糖尿病显著相关（p<0.05）。评估的任何 25(OH)D 代谢物均无统计学意义上的变化。多变量分析显示 BMI 与重要炎症和代谢危险因素之间存在显著和独立的关联（p<0.05）。未观察到与 25(OH)D 代谢物类似的关联。
尽管我们发现 25(OH)D 与 2 型糖尿病的患病率之间存在显著关联，但我们没有证据支持 25(OH)D 代谢物在介导 BMI 对炎症或代谢危险因素的影响中的作用。
