Department of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Department of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China; Key University Laboratory of Pharmaceutics & Drug Delivery Systems of Shandong Province, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China; Pediatric Pharmaceutical Engineering Laboratory of Shandong Province, Shandong Dyne Marine Biopharmaceutical Company Limited, Rongcheng, Shandong 264300, PR China; Chemical Immunopharmaceutical Engineering Laboratory of Shandong Province, Shandong Xili Pharmaceutical Company Limited, Heze, Shandong 274300, PR China.
Int J Pharm. 2022 Jan 5;611:121289. doi: 10.1016/j.ijpharm.2021.121289. Epub 2021 Nov 11.
The unique properties of polymers have performed an essential contribution to the drug delivery system by providing an outstanding platform for the delivery of macromolecules and genes. However, the block copolymers have been the subject of many recently published works whose results have demonstrated excellent performance in drug targeting. Poly(β-amino esters) (PβAEs) copolymers are the synthetic cationic polymers that are tailored by chemically joining PβAEs with other additives to demonstrate extraordinary efficiency in designing pre-defined and pre-programmed nanostructures, site-specific delivery, andovercoming the distinct cellular barriers. Different compositional and structural libraries could be generated by combinatorial chemistry and by the addition of various novel functional additives that fulfill the multiple requirements of targeted delivery. These intriguing attributes allow PβAE-copolymers to have customized therapeutic functions such as excellent encapsulation capacity, high stability, and stimuli-responsive release. Here, we give an overview of PβAE copolymers-based formulations along with focusing on most notable improvements such as structural modifications, bio-conjugations, and stimuli-responsive approaches, for safe and effective nucleic acids delivery.
聚合物的独特性质通过为大分子和基因的输送提供出色的平台，对药物输送系统做出了重要贡献。然而，嵌段共聚物一直是许多最近发表的工作的主题，其结果表明在药物靶向方面具有优异的性能。聚（β-氨基酯）（PβAE）共聚物是通过化学连接 PβAE 与其他添加剂合成的阳离子聚合物，在设计预定义和预编程的纳米结构、定点输送以及克服明显的细胞屏障方面表现出非凡的效率。通过组合化学和添加各种满足靶向输送多种要求的新型功能添加剂，可以生成不同的组成和结构库。这些有趣的属性使 PβAE 共聚物具有定制的治疗功能，例如出色的封装能力、高稳定性和对刺激的响应性释放。在这里，我们概述了基于 PβAE 共聚物的制剂，重点介绍了结构修饰、生物缀合和对刺激的响应方法等最显著的改进，以实现安全有效的核酸输送。
