Azubuike Christopher C, Allemann Marco N, Michener Joshua K
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA.
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA.
Curr Opin Microbiol. 2022 Feb;65:64-72. doi: 10.1016/j.mib.2021.10.014. Epub 2021 Nov 11.
Lignin is an abundant and sustainable source of aromatic compounds that can be converted to value-added products. However, lignin is underutilized, since depolymerization produces a complex mixture of aromatic compounds that is difficult to convert to a single product. Microbial conversion of mixed aromatic substrates provides a potential solution to this conversion challenge. Recent advances have expanded the range of lignin-derived aromatic substrates that can be assimilated and demonstrated efficient conversion via central metabolism to new potential products. The development of additional non-model microbial hosts and genetic tools for these hosts have accelerated engineering efforts. However, yields with real depolymerized lignin are still low, and additional work will be required to achieve viable conversion processes.
木质素是一种丰富且可持续的芳香族化合物来源，可转化为高附加值产品。然而，木质素的利用不足，因为解聚会产生难以转化为单一产品的复杂芳香族化合物混合物。混合芳香族底物的微生物转化为这一转化挑战提供了潜在的解决方案。最近的进展扩大了可被同化的木质素衍生芳香族底物的范围，并证明了通过中心代谢可高效转化为新的潜在产品。其他非模式微生物宿主以及这些宿主的遗传工具的开发加速了工程研究工作。然而，实际解聚木质素的产量仍然很低，还需要开展更多工作才能实现可行的转化过程。
