Smits Wiep Klaas, Roseboom Anna Maria, Corver Jeroen
Experimental Bacteriology Group, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands; Centre for Microbial Cell Biology, Leiden, The Netherlands; Leiden University Center for Infectious Diseases (LU-CID), Leiden, The Netherlands.
Experimental Bacteriology Group, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Curr Opin Microbiol. 2022 Feb;65:87-94. doi: 10.1016/j.mib.2021.10.016. Epub 2021 Nov 11.
Plasmids are ubiquitous in the bacterial world. In many microorganisms, plasmids have been implicated in important aspects of bacterial physiology and contribute to horizontal gene transfer. In contrast, knowledge on plasmids of the enteropathogen Clostridioides difficile is limited, and there appears to be no phenotypic consequence to carriage of many of the identified plasmids. Emerging evidence suggests, however, that plasmids are common in C. difficile and may encode functions relevant to pathogenesis, such as antimicrobial resistance and toxin production. Here, we review our current knowledge about the abundance, functions and clinical relevance of plasmids in C. difficile.
质粒在细菌世界中无处不在。在许多微生物中，质粒与细菌生理学的重要方面有关，并有助于水平基因转移。相比之下，关于肠道病原体艰难梭菌质粒的知识有限，而且许多已鉴定的质粒携带似乎没有表型后果。然而，新出现的证据表明，质粒在艰难梭菌中很常见，并且可能编码与发病机制相关的功能，如抗菌抗性和毒素产生。在这里，我们综述了目前关于艰难梭菌中质粒的丰度、功能和临床相关性的知识。
